A Systematic Review of Cost-Effectiveness Studies of Interventions With a Personalized Nutrition Component in Adults

Milanne M.J. Galekop*, Carin A. Uyl-de Groot, W. Ken Redekop

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Objectives: Important links between dietary patterns and diseases have been widely applied to establish nutrition interventions. However, knowledge about between-person heterogeneity regarding the benefits of nutrition intervention can be used to personalize the intervention and thereby improve health outcomes and efficiency. We performed a systematic review of cost-effectiveness analyses (CEAs) of interventions with a personalized nutrition (PN) component to assess their methodology and findings. Methods: A systematic search (March 2019) was performed in 5 databases: EMBASE, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. CEAs involving interventions in adults with a PN component were included; CEAs focusing on clinical nutrition or undernutrition were excluded. The CHEERS checklist was used to assess the quality of CEAs. Results: We identified 49 eligible studies among 1792 unique records. Substantial variation in methodology was found. Most studies (91%) focused only on psychological concepts of PN such as behavior and preferences. Thirty-four CEAs were trial-based, 13 were modeling studies, and 4 studies were both trial- and model-based. Thirty-two studies used quality-adjusted life year as an outcome measure. Different time horizons, comparators, and modeling assumptions were applied, leading to differences in costs/quality-adjusted life years. Twenty-eight CEAs (49%) concluded that the intervention was cost-effective, and 75% of the incremental cost-utility ratios were cost-effective given a willingness-to-pay threshold of $50 000 per quality-adjusted life year. Conclusions: Interventions with PN components are often evaluated using various types of models. However, most PN interventions have been considered cost-effective. More studies should examine the cost-effectiveness of PN interventions that combine psychological and biological concepts of personalization.

Original languageEnglish
Pages (from-to)325-335
Number of pages11
JournalValue in Health
Volume24
Issue number3
Early online date10 Feb 2021
DOIs
Publication statusPublished - 1 Mar 2021

Bibliographical note

Funding Information:
Funding/Support: This work was supported by grant No. 818318 from the European Union’s Horizon 2020 Union's Horizon 2020 research and innovation program (project named PREVENTOMICS).

Publisher Copyright:
© 2021 ISPOR–The Professional Society for Health Economics and Outcomes Research

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