A War of Exhaustion: T cell signatures in hepatitis B virus infection

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

Annually, a subset of chronic patients is capable of controlling hepatitis B virus (HBV) replication long-term, similar to what is observed following acute resolving HBV infection. A more detailed understanding of the immune responses associated with HBV resolution could pave the way for new immunotherapeutic interventions. We have studied HBV-specific T cell immunity in chronic HBV-infected patients, as well as in acute and chronic patients with long-term HBV control, as the natural model for protective immunity. We have characterized HBV-specific T cell responses, using: multicolor flowcytometry, HLA-class I and II multimers, intracellular cytokine staining and IFN-y ELISpot assays.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • Metselaar, Herold, Supervisor
  • Boonstra, Andre, Co-supervisor
  • Lauer, GM, Co-supervisor
Award date24 Feb 2022
Place of PublicationRotterdam
Print ISBNs978-94-6458-026-6
Publication statusPublished - 24 Feb 2022

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