A War of Exhaustion: T cell signatures in hepatitis B virus infection

Ruben Hoogeveen

A War of Exhaustion: T cell signatures in hepatitis B virus infection

Ruben Hoogeveen

Gastroenterology & Hepatology

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

Annually, a subset of chronic patients is capable of controlling hepatitis B virus (HBV) replication long-term, similar to what is observed following acute resolving HBV infection. A more detailed understanding of the immune responses associated with HBV resolution could pave the way for new immunotherapeutic interventions. We have studied HBV-specific T cell immunity in chronic HBV-infected patients, as well as in acute and chronic patients with long-term HBV control, as the natural model for protective immunity. We have characterized HBV-specific T cell responses, using: multicolor flowcytometry, HLA-class I and II multimers, intracellular cytokine staining and IFN-y ELISpot assays.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Metselaar, Herold, Supervisor Boonstra, Andre, Co-supervisor Lauer, GM, Co-supervisor, External person
Award date	24 Feb 2022
Place of Publication	Rotterdam
Print ISBNs	978-94-6458-026-6
Publication status	Published - 24 Feb 2022

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final dissertation HoogeveenFinal published version, 121 MBLicence: Unspecified
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Cite this

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N2 - Annually, a subset of chronic patients is capable of controlling hepatitis B virus (HBV) replication long-term, similar to what is observed following acute resolving HBV infection. A more detailed understanding of the immune responses associated with HBV resolution could pave the way for new immunotherapeutic interventions. We have studied HBV-specific T cell immunity in chronic HBV-infected patients, as well as in acute and chronic patients with long-term HBV control, as the natural model for protective immunity. We have characterized HBV-specific T cell responses, using: multicolor flowcytometry, HLA-class I and II multimers, intracellular cytokine staining and IFN-y ELISpot assays.

AB - Annually, a subset of chronic patients is capable of controlling hepatitis B virus (HBV) replication long-term, similar to what is observed following acute resolving HBV infection. A more detailed understanding of the immune responses associated with HBV resolution could pave the way for new immunotherapeutic interventions. We have studied HBV-specific T cell immunity in chronic HBV-infected patients, as well as in acute and chronic patients with long-term HBV control, as the natural model for protective immunity. We have characterized HBV-specific T cell responses, using: multicolor flowcytometry, HLA-class I and II multimers, intracellular cytokine staining and IFN-y ELISpot assays.

M3 - Doctoral Thesis

SN - 978-94-6458-026-6

CY - Rotterdam

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A War of Exhaustion: T cell signatures in hepatitis B virus infection

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