TY - JOUR
T1 - Aberrant neural network activation during reliving of autobiographical memories in adolescent depression
AU - van Houtum, Lisanne A.E.M.
AU - van Schie, Charlotte C.
AU - Wever, Mirjam C.M.
AU - Janssen, Loes H.C.
AU - Wentholt, Wilma G.M.
AU - Tailby, Chris
AU - Grenyer, Brin F.S.
AU - Will, Geert Jan
AU - Tollenaar, Marieke S.
AU - Elzinga, Bernet M.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/11
Y1 - 2023/11
N2 - Background: Adolescents with depression exhibit negative biases in autobiographical memory with detrimental consequences for their self-concept and well-being. Investigating how adolescents relive positive autobiographical memories and activate the underlying neural networks could reveal mechanisms that drive such biases. This study investigated neural networks when reliving positive and neutral memories, and how neural activity is modulated by valence and vividness in adolescents with and without depression. Methods: Adolescents (N = 69; n = 17 with depression) retrieved positive and neutral autobiographical memories. On a separate day, they relived these memories during fMRI scanning, and reported on pleasantness and vividness after reliving each memory. We used a multivariate, data-driven approach – event-related independent component analysis (eICA) – to characterize neural networks supporting autobiographical recollection. Results: Adolescents with depression reported their positive memories as significantly less pleasant compared to healthy controls, while subjective vividness was unaffected. Using eICA, we identified a broad autobiographical memory network, and subnetworks related to reliving positive vs neutral memories. These subnetworks comprised a ‘self-referential processing network’ including medial prefrontal cortex, posterior cingulate cortex/precuneus, and temporoparietal junction, anti-correlating with parts of the central executive network and salience network. Adolescents with depression exhibited aberrant activation in this self-referential network, but only when reliving relatively ‘low’ pleasant memories. Conclusions: Our findings provide first insights into how the quality of reliving autobiographical memories in adolescents with depression may relate to aberrant self-referential neural network activation, and underscore the potential of targeting memory reliving in therapeutic interventions to foster self-esteem and diminish depressive symptoms.
AB - Background: Adolescents with depression exhibit negative biases in autobiographical memory with detrimental consequences for their self-concept and well-being. Investigating how adolescents relive positive autobiographical memories and activate the underlying neural networks could reveal mechanisms that drive such biases. This study investigated neural networks when reliving positive and neutral memories, and how neural activity is modulated by valence and vividness in adolescents with and without depression. Methods: Adolescents (N = 69; n = 17 with depression) retrieved positive and neutral autobiographical memories. On a separate day, they relived these memories during fMRI scanning, and reported on pleasantness and vividness after reliving each memory. We used a multivariate, data-driven approach – event-related independent component analysis (eICA) – to characterize neural networks supporting autobiographical recollection. Results: Adolescents with depression reported their positive memories as significantly less pleasant compared to healthy controls, while subjective vividness was unaffected. Using eICA, we identified a broad autobiographical memory network, and subnetworks related to reliving positive vs neutral memories. These subnetworks comprised a ‘self-referential processing network’ including medial prefrontal cortex, posterior cingulate cortex/precuneus, and temporoparietal junction, anti-correlating with parts of the central executive network and salience network. Adolescents with depression exhibited aberrant activation in this self-referential network, but only when reliving relatively ‘low’ pleasant memories. Conclusions: Our findings provide first insights into how the quality of reliving autobiographical memories in adolescents with depression may relate to aberrant self-referential neural network activation, and underscore the potential of targeting memory reliving in therapeutic interventions to foster self-esteem and diminish depressive symptoms.
UR - http://www.scopus.com/inward/record.url?scp=85168732342&partnerID=8YFLogxK
U2 - 10.1016/j.cortex.2023.06.021
DO - 10.1016/j.cortex.2023.06.021
M3 - Article
C2 - 37639906
AN - SCOPUS:85168732342
SN - 0010-9452
VL - 168
SP - 14
EP - 26
JO - Cortex
JF - Cortex
ER -