TY - JOUR
T1 - Accuracy and reproducibility of quantitation of left ventricular function by real-time three-dimensional echocardiography versus cardiac magnetic resonance
AU - Soliman, Osama
AU - Kirschbaum, Sharon
AU - van Dalen, Bas
AU - Zwaan, Heleen
AU - Delavary, BM
AU - Vletter, Wim
AU - van Geuns, Robert Jan
AU - ten Cate, Folkert
AU - Geleijnse, Marcel
PY - 2008
Y1 - 2008
N2 - The aim of this study was to investigate the accuracy and reproducibility of the quantification of left ventricular (LV) function by real-time 3-dimensional echocardiography (RT3DE) using current state-of-the-art hardware and software. Compared with cardiac magnetic resonance (CMR), previous generations of hardware and software for RT3DE significantly underestimated LV volumes partly because of inherent factors such as limited spatial and temporal resolution. Also, RT3DE volumes were compared with short-axis CMR data, whereas a combined short-axis and long-axis analysis is known to be superior. Twenty-four subjects (mean age 51 +/- 12 years, 17 men) in sinus rhythm and with good to excellent 2-dimensional image quality underwent RUDE and CMR within 1 day. The acquisition of RUDE data was done with current state-of-the-art hardware and software. Two blinded experts performed off-line LV volume analysis. Global LV volumes were determined from semiautomated border detection on the basis of endocardial speckle tracking with biplane projections using QLAB version 6.0. Volumes derived by magnetic resonance imaging were quantified from combined short-axis and long-axis series. The volume-rate on RT3DE was 33 +/- 8 Hz (range 19 to 42). Excellent correlations were found (R-2 >= 0.97) between CMR and RT3DE for global LV end-diastolic volume, LV end-systolic volume, the LV ejection fraction, and LV phase volumes (24 phases/cardiac cycle). Bland-Altman analyses showed mean differences of -7.1 ml, -4.2 ml, 0.2%, and -5.8 ml and 95% limits of agreement of +/- 19.7 ml, +/- 8.3 ml, +/- 6.2%, and +/- 15.4 ml for global LV end-diastolic volume, LV end-systolic volume, the LV ejection fraction, and LV phase volumes, respectively. Interobserver variability was 5.2% for global LV end-diastolic volume, 6.4% for LV end-systolic volume, and 7.6% for the LV ejection fraction. In conclusion, in patients with good acoustic windows, RUDE using state-of-the-art technology provides accurate and reproducible measurements of global LV volumes, LV volume changes over time, and the LV ejection fraction. (C) 2008 Elsevier Inc. All rights reserved.
AB - The aim of this study was to investigate the accuracy and reproducibility of the quantification of left ventricular (LV) function by real-time 3-dimensional echocardiography (RT3DE) using current state-of-the-art hardware and software. Compared with cardiac magnetic resonance (CMR), previous generations of hardware and software for RT3DE significantly underestimated LV volumes partly because of inherent factors such as limited spatial and temporal resolution. Also, RT3DE volumes were compared with short-axis CMR data, whereas a combined short-axis and long-axis analysis is known to be superior. Twenty-four subjects (mean age 51 +/- 12 years, 17 men) in sinus rhythm and with good to excellent 2-dimensional image quality underwent RUDE and CMR within 1 day. The acquisition of RUDE data was done with current state-of-the-art hardware and software. Two blinded experts performed off-line LV volume analysis. Global LV volumes were determined from semiautomated border detection on the basis of endocardial speckle tracking with biplane projections using QLAB version 6.0. Volumes derived by magnetic resonance imaging were quantified from combined short-axis and long-axis series. The volume-rate on RT3DE was 33 +/- 8 Hz (range 19 to 42). Excellent correlations were found (R-2 >= 0.97) between CMR and RT3DE for global LV end-diastolic volume, LV end-systolic volume, the LV ejection fraction, and LV phase volumes (24 phases/cardiac cycle). Bland-Altman analyses showed mean differences of -7.1 ml, -4.2 ml, 0.2%, and -5.8 ml and 95% limits of agreement of +/- 19.7 ml, +/- 8.3 ml, +/- 6.2%, and +/- 15.4 ml for global LV end-diastolic volume, LV end-systolic volume, the LV ejection fraction, and LV phase volumes, respectively. Interobserver variability was 5.2% for global LV end-diastolic volume, 6.4% for LV end-systolic volume, and 7.6% for the LV ejection fraction. In conclusion, in patients with good acoustic windows, RUDE using state-of-the-art technology provides accurate and reproducible measurements of global LV volumes, LV volume changes over time, and the LV ejection fraction. (C) 2008 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.amjcard.2008.04.062
DO - 10.1016/j.amjcard.2008.04.062
M3 - Article
SN - 0002-9149
VL - 102
SP - 778
EP - 783
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -