Acoustic behavior of microbubbles and implications for drug delivery

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Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they increasingly show potential for drug delivery. This review focuses on the acoustic behavior of flexible-coated microbubbles and rigid-coated microcapsules and their contribution to enhanced drug delivery. Phenomena relevant to drug delivery, such as non-spherical oscillations, shear stress, microstreaming, and jetting will be reviewed from both a theoretical and experimental perspective. Further, the two systems for drug delivery, co-administration and the microbubble as drug carrier system, are reviewed in relation to the microbubble behavior. Finally, future prospects are discussed that need to be addressed for ultrasound contrast agents to move from a pre-clinical tool into a clinical setting. (C) 2014 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)28-48
Number of pages21
JournalAdvanced Drug Delivery Reviews
Publication statusPublished - 15 Jun 2014

Bibliographical note

This research is partly supported by the Center for Translational Molecular Medicine and the Dutch Heart Foundation (PARISk), and by
NanoNextNL, a micro and nanotechnology consortium of the Government of the Netherlands and 130 partners. This work is also partly
financed by the Foundation for Fundamental Research on Matter FOM and the Technology Foundation STW. It is also supported by TAMIRUT,
a Specific Targeted Research (STReP) project supported by the 6th Framework Programme of the European Commission in the
Nanosciences, Nanotechnologies, Materials and new Production Technologies area under contract number NMP4-CT-2005-016382, by the
Innovation Subsidies collaborative projects by the Dutch Ministry of Economic Affairs under nr. IS042035, and by the Sonodrugs Project
(NMP-2008-213706). It is also supported by the Interuniversity Cardiology Institute of the Netherlands (ICIN), and through a personal 2012
ICIN Fellowship (KK). The authors thank Dr. Marcel R. Böhmer and Ceciel Chlon from Philips Research Europe, Eindhoven, for providing
the pLA–pFO microcapsules.


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