Activation and effector functions of human RORC plus innate lymphoid cells

Ferry Cornelissen, Patricia Aparicio Domingo, Rogier Reijmers, Tom Cupedo

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10 Citations (Scopus)


Innate lymphoid cells expressing the nuclear hormone receptor RORC have emerged as important players in human mucosal immunity. These cells combine innate modes of activation such as Toll-like receptor signaling with secretion of adaptive effector molecules including IL-2, BAFF and the Th17 cytokines IL-17 and IL-22. This endows these cells with the ability to rapidly respond to changes in cytokine milieu as well as changes in microbial composition and to affect both intestinal homeostasis and activation of adaptive immune cells.
Original languageUndefined/Unknown
Pages (from-to)361-367
Number of pages7
JournalCurrent Opinion in Immunology
Issue number3
Publication statusPublished - 2011

Research programs

  • EMC MM-02-41-04

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