Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

ACM van Esbroeck; APA Janssen; AB Cognetta; D Ogasawara; Guy Shpak; Mark Kroeg; V Kantae; MP Baggelaar; Femke de Vrij; H Deng; M Allara; F Fezza; Zhanmin Lin; Twan Wel; M Soethoudt; ED Mock; H den Dulk; IL Baak; BI Florea; G Hendriks; L de Petrocellis; HS Overkleeft; T Hankemeier; Chris de Zeeuw; V Di Marzo; M Maccarrone; BF Cravatt; Steven Kushner; M van der Stelt

doi:10.1126/science.aaf7497

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

ACM van Esbroeck
, APA Janssen
, AB Cognetta
, D Ogasawara
, Guy Shpak
, Mark Kroeg
, V Kantae
, MP Baggelaar
, Femke de Vrij
, H Deng
, M Allara
, F Fezza
, Zhanmin Lin
, Twan Wel
, M Soethoudt
, ED Mock
, H den Dulk
, IL Baak
, BI Florea
, G Hendriks

L de Petrocellis, HS Overkleeft, T Hankemeier, Chris de Zeeuw, V Di Marzo, M Maccarrone, BF Cravatt, Steven Kushner, M van der Stelt

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

279 Citations (Scopus)

130 Downloads (Pure)

Original language	Undefined/Unknown
Pages (from-to)	1084-1087
Number of pages	4
Journal	Science
Volume	356
Issue number	6342
DOIs	https://doi.org/10.1126/science.aaf7497
Publication status	Published - 2017

Research programs

EMC OR-01

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10.1126/science.aaf7497

Repub_119863_O-A.pdfFinal published version, 628 KB

http://hdl.handle.net/1765/100560

Cite this

van Esbroeck, ACM., Janssen, APA., Cognetta, AB., Ogasawara, D., Shpak, G., Kroeg, M., Kantae, V., Baggelaar, MP., de Vrij, F., Deng, H., Allara, M., Fezza, F., Lin, Z., Wel, T., Soethoudt, M., Mock, ED., den Dulk, H., Baak, IL., Florea, BI., ... van der Stelt, M. (2017). Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science, 356(6342), 1084-1087. https://doi.org/10.1126/science.aaf7497

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van Esbroeck, ACM, Janssen, APA, Cognetta, AB, Ogasawara, D, Shpak, G, Kroeg, M, Kantae, V, Baggelaar, MP, de Vrij, F, Deng, H, Allara, M, Fezza, F, Lin, Z, Wel, T, Soethoudt, M, Mock, ED, den Dulk, H, Baak, IL, Florea, BI, Hendriks, G, de Petrocellis, L, Overkleeft, HS, Hankemeier, T, de Zeeuw, C, Di Marzo, V, Maccarrone, M, Cravatt, BF, Kushner, S & van der Stelt, M 2017, 'Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474', Science, vol. 356, no. 6342, pp. 1084-1087. https://doi.org/10.1126/science.aaf7497

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T1 - Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

AU - van Esbroeck, ACM

AU - Janssen, APA

AU - Cognetta, AB

AU - Ogasawara, D

AU - Shpak, Guy

AU - Kroeg, Mark

AU - Kantae, V

AU - Baggelaar, MP

AU - de Vrij, Femke

AU - Deng, H

AU - Allara, M

AU - Fezza, F

AU - Lin, Zhanmin

AU - Wel, Twan

AU - Soethoudt, M

AU - Mock, ED

AU - den Dulk, H

AU - Baak, IL

AU - Florea, BI

AU - Hendriks, G

AU - de Petrocellis, L

AU - Overkleeft, HS

AU - Hankemeier, T

AU - de Zeeuw, Chris

AU - Di Marzo, V

AU - Maccarrone, M

AU - Cravatt, BF

AU - Kushner, Steven

AU - van der Stelt, M

PY - 2017

Y1 - 2017

U2 - 10.1126/science.aaf7497

DO - 10.1126/science.aaf7497

M3 - Article

C2 - 28596366

SN - 0036-8075

VL - 356

SP - 1084

EP - 1087

JO - Science

JF - Science

IS - 6342

ER -