Acute Disseminating Encephalomyelitis Following Legionnaires Disease

Lonneke Lau, Dorine Siepman, MJM Remmers, GM Terwindt, Rogier Hintzen

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Objective: To describe 2 patients presenting with severe neurological deficits and extensive lesions on brain magnetic resonance imaging after having experienced Legionella pneumonia. Design: Case reports. Setting: University hospital. Patients: Two patients who developed severe neurological symptoms, including encephalopathic signs, following Legionella infection, with widespread lesions on magnetic resonance imaging compatible with demyelination. Results: After extensive ancillary investigations, a diagnosis of acute disseminating encephalomyelitis was considered most likely. Steroid therapy was initiated in 1 of the patients, followed by plasmapheresis. In both patients, clinical and radiological signs gradually recovered, with only slight residual deficits. Conclusion: In patients presenting with neurological symptoms after an episode of pneumonia, Legionella infection and a subsequent immune-mediated process such as acute disseminating encephalomyelitis should be considered.
Original languageUndefined/Unknown
Pages (from-to)623-626
Number of pages4
JournalArchives of Neurology
Issue number5
Publication statusPublished - 2010

Research programs

  • EMC COEUR-09
  • EMC MM-04-44-02

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