Adaptation of Pandemic H2N2 Influenza A Viruses in Humans

U Joseph; Martin Linster; Y Suzuki; S Krauss; RA Halpin; D Vijaykrishna; TP Fabrizio; Theo Bestebroer; S Maurer-Stroh; RJ Webby; DE Wentworth; Ron Fouchier; J Bahl; GJD Smith

doi:10.1128/JVI.02590-14

Adaptation of Pandemic H2N2 Influenza A Viruses in Humans

U Joseph, Martin Linster, Y Suzuki, S Krauss, RA Halpin, D Vijaykrishna, TP Fabrizio, Theo Bestebroer, S Maurer-Stroh, RJ Webby, DE Wentworth, Ron Fouchier, J Bahl, GJD Smith

Virology

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.

Original language	Undefined/Unknown
Pages (from-to)	2442-2447
Number of pages	6
Journal	Journal of Virology
Volume	89
Issue number	4
DOIs	https://doi.org/10.1128/JVI.02590-14
Publication status	Published - 2015

Research programs

EMC MM-04-27-01

Access to Document

10.1128/JVI.02590-14

http://hdl.handle.net/1765/81364

Cite this

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AU - Joseph, U

AU - Linster, Martin

AU - Suzuki, Y

AU - Krauss, S

AU - Halpin, RA

AU - Vijaykrishna, D

AU - Fabrizio, TP

AU - Bestebroer, Theo

AU - Maurer-Stroh, S

AU - Webby, RJ

AU - Wentworth, DE

AU - Fouchier, Ron

AU - Bahl, J

AU - Smith, GJD

PY - 2015

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AB - The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.

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DO - 10.1128/JVI.02590-14

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