Adaptations in the glucose metabolism of procyclic Trypanosoma brucei isolates from tsetse flies and during differentiation of bloodstream forms

Koen W.A. Van Grinsven; Jan Van Den Abbeele; Peter Van Den Bossche; Jaap J. Van Hellemond; Aloysius G.M. Tielens

doi:10.1128/EC.00091-09

Adaptations in the glucose metabolism of procyclic Trypanosoma brucei isolates from tsetse flies and during differentiation of bloodstream forms

Koen W.A. Van Grinsven
, Jan Van Den Abbeele
, Peter Van Den Bossche
, Jaap J. Van Hellemond
, Aloysius G.M. Tielens

Medical Microbiology & Infectious Diseases

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Procyclic forms of Trypanosoma brucei isolated from the midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle. Furthermore, short stumpy bloodstream forms produce acetate and are apparently metabolically preadapted to adequate functioning in the tsetse fly.

Original language	English
Pages (from-to)	1307-1311
Number of pages	5
Journal	Eukaryotic Cell
Volume	8
Issue number	8
DOIs	https://doi.org/10.1128/EC.00091-09
Publication status	Published - Aug 2009

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abstract = "Procyclic forms of Trypanosoma brucei isolated from the midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle. Furthermore, short stumpy bloodstream forms produce acetate and are apparently metabolically preadapted to adequate functioning in the tsetse fly.",

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AU - Van Hellemond, Jaap J.

AU - Tielens, Aloysius G.M.

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AB - Procyclic forms of Trypanosoma brucei isolated from the midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle. Furthermore, short stumpy bloodstream forms produce acetate and are apparently metabolically preadapted to adequate functioning in the tsetse fly.

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Adaptations in the glucose metabolism of procyclic Trypanosoma brucei isolates from tsetse flies and during differentiation of bloodstream forms

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