Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

APJ de Pagter, LM Haveman, R (Rob) Schuurman, Martin Schutten, M Bierings, JJ Boelens

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Abstract

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.
Original languageUndefined/Unknown
Pages (from-to)1536-1539
Number of pages4
JournalClinical Infectious Diseases
Volume49
Issue number10
DOIs
Publication statusPublished - 2009

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