Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

APJ de Pagter; LM Haveman; R (Rob) Schuurman; Martin Schutten; M Bierings; JJ Boelens

doi:10.1086/644739

Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

APJ de Pagter
, LM Haveman
, R (Rob) Schuurman
, Martin Schutten
, M Bierings
, JJ Boelens

Virology

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

Original language	Undefined/Unknown
Pages (from-to)	1536-1539
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	49
Issue number	10
DOIs	https://doi.org/10.1086/644739
Publication status	Published - 2009

Research programs

EMC MM-04-27-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1086/644739

http://hdl.handle.net/1765/24628

Cite this

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abstract = "Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.",

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Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients. / de Pagter, APJ; Haveman, LM; Schuurman, R (Rob) et al.
In: Clinical Infectious Diseases, Vol. 49, No. 10, 2009, p. 1536-1539.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Schutten, Martin

AU - Bierings, M

AU - Boelens, JJ

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AB - Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

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