Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa

Hylke Waalewijn; Kim Stol; Linda van der Knaap; Pieter L.A. Fraaij; Clementien Vermont; Annemarie M.C. van Rossum; Riet Strik-Albers; David M. Burger; Elin M. Svensson; Angela Colbers

doi:10.1097/QAD.0000000000003350

Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa

Hylke Waalewijn, Kim Stol, Linda van der Knaap, Pieter L.A. Fraaij, Clementien Vermont, Annemarie M.C. van Rossum, Riet Strik-Albers, David M. Burger, Elin M. Svensson, Angela Colbers

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Abstract

Dolutegravir 50 mg is registered for use in children weighing 20-40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.

Original language	English
Pages (from-to)	2077-2079
Number of pages	3
Journal	AIDS (London, England)
Volume	36
Issue number	14
DOIs	https://doi.org/10.1097/QAD.0000000000003350
Publication status	Published - 15 Nov 2022

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Cite this

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title = "Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa",

abstract = "Dolutegravir 50 mg is registered for use in children weighing 20-40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.",

author = "Hylke Waalewijn and Kim Stol and {van der Knaap}, Linda and Fraaij, {Pieter L.A.} and Clementien Vermont and {van Rossum}, {Annemarie M.C.} and Riet Strik-Albers and Burger, {David M.} and Svensson, {Elin M.} and Angela Colbers",

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T1 - Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa

AU - Waalewijn, Hylke

AU - Stol, Kim

AU - van der Knaap, Linda

AU - Fraaij, Pieter L.A.

AU - Vermont, Clementien

AU - van Rossum, Annemarie M.C.

AU - Strik-Albers, Riet

AU - Burger, David M.

AU - Svensson, Elin M.

AU - Colbers, Angela

PY - 2022/11/15

Y1 - 2022/11/15

N2 - Dolutegravir 50 mg is registered for use in children weighing 20-40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.

AB - Dolutegravir 50 mg is registered for use in children weighing 20-40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.

UR - http://www.scopus.com/inward/record.url?scp=85140932744&partnerID=8YFLogxK

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DO - 10.1097/QAD.0000000000003350

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JF - AIDS (London, England)

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