Adequate exposure of 50 mg dolutegravir in children weighing 20 to 40 kg outside of sub-Sahara Africa

Hylke Waalewijn, Kim Stol, Linda van der Knaap, Pieter L.A. Fraaij, Clementien Vermont, Annemarie M.C. van Rossum, Riet Strik-Albers, David M. Burger, Elin M. Svensson, Angela Colbers

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Abstract

Dolutegravir 50 mg is registered for use in children weighing 20-40 kg. This approval is based on data from an African paediatric cohort, and no pharmacokinetic data was available from children outside of Africa. This study provides further evidence of the effective use of dolutegravir 50 mg in children weighing 20 to 40 kg by showing that concentration data gathered in clinical practice shows adequate concentration levels in Dutch children without a safety signal.

Original languageEnglish
Pages (from-to)2077-2079
Number of pages3
JournalAIDS (London, England)
Volume36
Issue number14
DOIs
Publication statusPublished - 15 Nov 2022

Bibliographical note

Publisher Copyright: Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

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