Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee

Jacob M. Mostert, Niels B.J. Dur, Xiufeng Li, Jutta M. Ellermann, Robert Hemke, Laurel Hales, Valentina Mazzoli, Feliks Kogan, James F. Griffith, Edwin H.G. Oei, Rianne A. Van Der Heijden*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniques and molecular imaging facilitate more in-depth research focused on the pathophysiology of chronic musculoskeletal pain and more specifically inflammation. The forthcoming new insights can help develop better targeted treatment, and some imaging techniques may even serve as imaging biomarkers for predicting and assessing treatment response in the future. This review highlights the latest developments in perfusion MRI, diffusion MRI, and molecular imaging with positron emission tomography/MRI and their application in the painful knee. The primary focus is synovial inflammation, also known as synovitis. Bone perfusion and bone metabolism are also addressed.

Original languageEnglish
Pages (from-to)618-631
Number of pages14
JournalSeminars in Musculoskeletal Radiology
Issue number6
Publication statusPublished - 7 Nov 2023

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