Advances in multimodality carotid plaque imaging: AJR expert panel narrative review

Daniel Bos, Dianne H.K. van Dam-Nolen, Ajay Gupta, Luca Saba, David Saloner, Bruce A. Wasserman, Aad van der Lugt*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)
4 Downloads (Pure)


Contemporary imaging methods provide detailed visualization of carotid atherosclerotic plaque, enabling a major evolution of in vivo carotid plaque imaging evaluation. The degree of luminal stenosis in the carotid artery bifurcation, as assessed by ultrasound, has historically served as the primary imaging feature for determining ischemic stroke risk and the potential need for surgery. However, stroke risk may be more strongly driven by the presence of specific characteristics of vulnerable plaque, as visualized on CT and MRI, than by traditional ultrasound-based assessment of luminal narrowing. This review highlights six promising imaging-based plaque characteristics that harbor unique information regarding plaque vulnerability: maximum plaque thickness and volume, calcification, ulceration, intraplaque hemorrhage, lipid-rich necrotic core, and thin or ruptured fibrous cap. Increasing evidence supports the association of these plaque characteristics with risk of ischemic stroke, although these characteristics have varying suitability for clinical implementation. Key aspects of CT and MRI protocols for carotid plaque imaging are also considered. Practical next steps and hurdles are explored for implementing routine imaging assessment of these plaque characteristics in addition to, or even as replacement for, traditional assessment of the degree of vascular stenosis on ultrasound, in the identification of individuals at high risk of ischemic stroke.

Original languageEnglish
Pages (from-to)16-26
Number of pages11
JournalAmerican Journal of Roentgenology
Issue number1
Publication statusPublished - Jul 2021

Bibliographical note

Publisher Copyright:
© American Roentgen Ray Society


Dive into the research topics of 'Advances in multimodality carotid plaque imaging: AJR expert panel narrative review'. Together they form a unique fingerprint.

Cite this