Advancing lung organoids for COVID-19 research

Jelte van der Vaart, Mart M. Lamers, Bart L. Haagmans, Hans Clevers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
91 Downloads (Pure)

Abstract

The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus’ cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

Original languageEnglish
Article numberdmm049060
JournalDMM Disease Models and Mechanisms
Volume14
Issue number6
DOIs
Publication statusPublished - 28 Jun 2021

Bibliographical note

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© 2021 Company of Biologists Ltd. All rights reserved.

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