Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Martine Vrijheid*, Xavier Basagaña, Juan R. Gonzalez, Vincent W.V. Jaddoe, Genon Jensen, Hector C. Keun, Rosemary R.C. McEachan, Joana Porcel, Valerie Siroux, Morris A. Swertz, Cathrine Thomsen, Gunn Marit Aasvang, Sandra Andrušaitytė, Karine Angeli, Demetris Avraam, Ferran Ballester, Paul Burton, Mariona Bustamante, Maribel Casas, Leda ChatziCécile Chevrier, Natacha Cingotti, David Conti, Amélie Crépet, Payam Dadvand, Liesbeth Duijts, Esther van Enckevort, Ana Esplugues, Serena Fossati, Ronan Garlantezec, María Dolores Gómez Roig, Regina Grazuleviciene, Kristine B. Gützkow, Mònica Guxens, Sido Haakma, Ellen V.S. Hessel, Lesley Hoyles, Eleanor Hyde, Jana Klanova, Jacob D. van Klaveren, Andreas Kortenkamp, Laurent Le Brusquet, Ivonne Leenen, Aitana Lertxundi, Nerea Lertxundi, Christos Lionis, Sabrina Llop, Maria Jose Lopez-Espinosa, Sarah Lyon-Caen, Lea Maitre, Dan Mason, Sandrine Mathy, Edurne Mazarico, Tim Nawrot, Mark Nieuwenhuijsen, Rodney Ortiz, Marie Pedersen, Josep Perelló, Míriam Pérez-Cruz, Claire Philippat, Pavel Piler, Costanza Pizzi, Joane Quentin, Lorenzo Richiardi, Adrian Rodriguez, Theano Roumeliotaki, José Manuel Sabin Capote, Leonardo Santiago, Susana Santos, Alexandros P. Siskos, Katrine Strandberg-Larsen, Nikos Stratakis, Jordi Sunyer, Arthur Tenenhaus, Marina Vafeiadi, Rebecca C. Wilson, John Wright, Tiffany Yang, Remy Slama

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

Original languageEnglish
Pages (from-to)E166
JournalEnvironmental Epidemiology
Issue number5
Publication statusPublished - 1 Oct 2021

Bibliographical note

Funding Information:
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 874583-the Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project. This publication reflects only the authors' view and the European Commission is not responsible for any use that may be made of the information it contains. Dr. Dadvand is funded by a Ram?n y Cajal fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Finance. Drs. Casas and Guxens are funded by the Instituto de Salud Carlos III (MS16/00128, CPII18/00018). Drs. Chatzi and Conti were supported by the National Institute of Environmental Health Sciences (R21ES029681, R01ES029944, R01ES030364, R01ES030691, and P30ES007048). Additional funding from National Institutes of Health supported Dr. Conti (P01CA196569, R01CA140561) and Dr. Stratakis (P30DK048522). Investigators Drs. McEachan and Wright receive funding from the National Institute for Health Research under its Applied Research Collaboration Yorkshire and Humber. Dr. Jaddoe received funding from a Consolidator Grant from the European Research Council (ERC-2014-CoG-648916). Dr. Duijts received funding from the European Union's Horizon 2020 co-funded programme European Research Area Net on Biomarkers for Nutrition and Health (European Research Area Healthy Diet for a Healthy Life) (Early life programming of childhood health project [number 696295; 2017], ZonMW, The Netherlands [number 529051014; 2017]). Dr. Guxens received funding from the Agence Nationale de Securite Sanitaire de l'Alimentation de l'Environnement et du Travail (EST-18 RF-25). The views expressed are those of the author(s) and not necessarily those of the National Institute for Health Research or the Department of Health and Social Care.

Publisher Copyright: Copyright © 2021 The Authors.


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