TY - JOUR
T1 - Adverse late health outcomes among children treated with 3D radiotherapy techniques
T2 - Study design of the Dutch pediatric 3D-RT study
AU - Beijer, Josien G.M.
AU - Kok, Judith L.
AU - Janssens, Geert O.
AU - Streefkerk, Nina
AU - de Vries, Andrica C.H.
AU - Slagter, Cleo
AU - Maduro, John H.
AU - Kroon, Petra S.
AU - Grootenhuis, Martha A.
AU - van Dulmen-den Broeder, Eline
AU - Loonen, Jacqueline J.
AU - Wendling, Markus
AU - Tissing, Wim J.E.
AU - van der Pal, Helena J.
AU - Louwerens, Marloes
AU - Bel, Arjan
AU - den Hartogh, Jaap
AU - van der Heiden-van der Loo, Margriet
AU - Kremer, Leontien C.M.
AU - Teepen, Jop C.
AU - Ronckers, Cécile M.
N1 - Publisher Copyright:
© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.
PY - 2023/2
Y1 - 2023/2
N2 - Background: Adverse late health outcomes after multimodal treatment for pediatric cancer are diverse and of prime interest. Currently available evidence and survivorship care guidelines are largely based on studies addressing side-effects of two dimensional planned radiotherapy. Aims: The Dutch pediatric 3D-planned radiotherapy (3D-RT) study aims to gain insight in the long-term health outcomes among children who had radiotherapy in the 3D era. Here, we describe the study design, data-collection methods, and baseline cohort characteristics. Methods and Results: The 3D-RT study represents an expansion of the Dutch Childhood Cancer Survivor study (DCCSS) LATER cohort, including pediatric cancer patients diagnosed during 2000–2012, who survived at least 5 years after initial diagnosis and 2 years post external beam radiotherapy. Individual cancer treatment parameters were obtained from medical files. A national infrastructure for uniform collection and archival of digital radiotherapy files (Computed Tomography [CT]-scans, delineations, plan, and dose files) was established. Health outcome information, including subsequent tumors, originated from medical records at the LATER outpatient clinics, and national registry-linkage. With a median follow-up of 10.9 (interquartile range [IQR]: 7.9–14.3) years after childhood cancer diagnosis, 711 eligible survivors were identified. The most common cancer types were Hodgkin lymphoma, medulloblastoma, and nephroblastoma. Most survivors received radiotherapy directed to the head/cranium only, the craniospinal axis, or the abdominopelvic region. Conclusion: The 3D-RT study will provide knowledge on the risk of adverse late health outcomes and radiation-associated dose-effect relationships. This information is valuable to guide follow-up care of childhood cancer survivors and to refine future treatment protocols.
AB - Background: Adverse late health outcomes after multimodal treatment for pediatric cancer are diverse and of prime interest. Currently available evidence and survivorship care guidelines are largely based on studies addressing side-effects of two dimensional planned radiotherapy. Aims: The Dutch pediatric 3D-planned radiotherapy (3D-RT) study aims to gain insight in the long-term health outcomes among children who had radiotherapy in the 3D era. Here, we describe the study design, data-collection methods, and baseline cohort characteristics. Methods and Results: The 3D-RT study represents an expansion of the Dutch Childhood Cancer Survivor study (DCCSS) LATER cohort, including pediatric cancer patients diagnosed during 2000–2012, who survived at least 5 years after initial diagnosis and 2 years post external beam radiotherapy. Individual cancer treatment parameters were obtained from medical files. A national infrastructure for uniform collection and archival of digital radiotherapy files (Computed Tomography [CT]-scans, delineations, plan, and dose files) was established. Health outcome information, including subsequent tumors, originated from medical records at the LATER outpatient clinics, and national registry-linkage. With a median follow-up of 10.9 (interquartile range [IQR]: 7.9–14.3) years after childhood cancer diagnosis, 711 eligible survivors were identified. The most common cancer types were Hodgkin lymphoma, medulloblastoma, and nephroblastoma. Most survivors received radiotherapy directed to the head/cranium only, the craniospinal axis, or the abdominopelvic region. Conclusion: The 3D-RT study will provide knowledge on the risk of adverse late health outcomes and radiation-associated dose-effect relationships. This information is valuable to guide follow-up care of childhood cancer survivors and to refine future treatment protocols.
UR - http://www.scopus.com/inward/record.url?scp=85147269339&partnerID=8YFLogxK
U2 - 10.1002/cnr2.1620
DO - 10.1002/cnr2.1620
M3 - Article
C2 - 36715495
AN - SCOPUS:85147269339
SN - 2573-8348
VL - 6
JO - Cancer Reports
JF - Cancer Reports
IS - 2
M1 - e1620
ER -
