Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent

Marcel Geleijnse, A (Attila) Nemes, Wim Vletter, Michelle Michels, Osama Soliman, Kadir Caliskan, Tjebbe Galema, Folkert ten Cate

Research output: Contribution to journalArticleAcademic

45 Citations (Scopus)


The aim of the present study was to analyse the adverse effects of SonoVue echo contrast in a consecutive series of 352 cardiac patients during a 4-year period. During 352 consecutive cardiac SonoVue studies, seven patients (2.0%) experienced adverse effects. Four patients (1.1%) had mild allergic reactions causing skin erythema and mild sinus tachycardia, and three patients (0.9%) experienced a severe allergic reaction resulting in (nonfatal) shock. The reported incidence of adverse effects of SonoVue echo contrast in this consecutive series of cardiac patients seems markedly higher than those reported in a company postmarketing analysis.
Original languageUndefined/Unknown
Pages (from-to)75-77
Number of pages3
JournalJournal of Cardiovascular Medicine
Issue number1
Publication statusPublished - 2009

Research programs

  • EMC COEUR-09

Cite this