Af inducibility is related to conduction abnormalities at bachmann’s bundle

Lianne N. van Staveren; Willemijn F.B. van der Does; Annejet Heida; Yannick J.H.J. Taverne; Ad J.J.C. Bogers; Natasja M.S. de Groot

doi:10.3390/jcm10235536

Af inducibility is related to conduction abnormalities at bachmann’s bundle

Lianne N. van Staveren, Willemijn F.B. van der Does, Annejet Heida, Yannick J.H.J. Taverne, Ad J.J.C. Bogers, Natasja M.S. de Groot^*

^*Corresponding author for this work

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Abstract

We investigated whether patterns of activation at Bachmann’s bundle are related to AF inducibility. Epicardial mapping of Bachmann’s bundle during sinus rhythm was performed prior to cardiac surgery (192 electrodes, interelectrode distances: 2 mm). Compared to non‐inducible patients (N = 20), patients with inducible AF (N = 34) had longer lines of conduction block (18(2– 164) mm vs. 6(2–28) mm, p = 0.048), prolonged total activation time (55(28–143) ms vs. 46(24–73) ms, p = 0.012), multiple wavefronts entering Bachmann’s bundle more frequently (64% vs. 37%, p = 0.046) and more often areas of simultaneous activation (conduction velocity > 1.7 m/s, 45% vs. 16%, p = 0.038). These observations further support a relation between conduction abnormalities at Bachmann’s bundle and AF inducibility. The next step is to examine whether Bachmann’s bundle activation patterns can also be used to identify patients who will develop AF after cardiac surgery during both short‐ and long‐term follow‐up.

Original language	English
Article number	5536
Journal	Journal of Clinical Medicine
Volume	10
Issue number	23
DOIs	https://doi.org/10.3390/jcm10235536
Publication status	Published - 26 Nov 2021

Bibliographical note

Funding Information:
Funding: N.M.S. de Groot is supported by funding grants from CVON‐AFFIP (914728), NWO‐Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS‐331) was conducted with financial support from the Investigator‐Initiated Study Program of Biosense Webster, Inc.

Funding Information:
N.M.S. de Groot is supported by funding grants from CVON?AFFIP (914728), NWO?Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS?331) was conducted with financial support from the Investigator?Initiated Study Program of Biosense Webster, Inc. The authors would like to kindly thank our colleagues A. Yaksh, C.P. Teuwen, E.A.H. Lanters, J.M.E. van der Does, E.M.J.P. Mouws, C.A. Houck, R. Starreveld, C.S. Serban and R.K. Kharbanda for their help with acquiring the mapping data, and we would also like to kindly thank the cardiothoracic surgeons J.A. Bekkers, W.J. van Leeuwen, F.B.S. Oei, F.R.N. van Schaagen and P.C. van de Woestijne for their contribution to this work.

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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AF Inducibility Is Related to Conduction Abnormalities at Bachmann’s BundleFinal published version, 1.85 MBLicence: CC BY

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title = "Af inducibility is related to conduction abnormalities at bachmann{\textquoteright}s bundle",

abstract = "We investigated whether patterns of activation at Bachmann{\textquoteright}s bundle are related to AF inducibility. Epicardial mapping of Bachmann{\textquoteright}s bundle during sinus rhythm was performed prior to cardiac surgery (192 electrodes, interelectrode distances: 2 mm). Compared to non‐inducible patients (N = 20), patients with inducible AF (N = 34) had longer lines of conduction block (18(2– 164) mm vs. 6(2–28) mm, p = 0.048), prolonged total activation time (55(28–143) ms vs. 46(24–73) ms, p = 0.012), multiple wavefronts entering Bachmann{\textquoteright}s bundle more frequently (64% vs. 37%, p = 0.046) and more often areas of simultaneous activation (conduction velocity > 1.7 m/s, 45% vs. 16%, p = 0.038). These observations further support a relation between conduction abnormalities at Bachmann{\textquoteright}s bundle and AF inducibility. The next step is to examine whether Bachmann{\textquoteright}s bundle activation patterns can also be used to identify patients who will develop AF after cardiac surgery during both short‐ and long‐term follow‐up.",

author = "{van Staveren}, {Lianne N.} and {van der Does}, {Willemijn F.B.} and Annejet Heida and Taverne, {Yannick J.H.J.} and Bogers, {Ad J.J.C.} and {de Groot}, {Natasja M.S.}",

note = "Funding Information: Funding: N.M.S. de Groot is supported by funding grants from CVON‐AFFIP (914728), NWO‐Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS‐331) was conducted with financial support from the Investigator‐Initiated Study Program of Biosense Webster, Inc. Funding Information: N.M.S. de Groot is supported by funding grants from CVON?AFFIP (914728), NWO?Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS?331) was conducted with financial support from the Investigator?Initiated Study Program of Biosense Webster, Inc. The authors would like to kindly thank our colleagues A. Yaksh, C.P. Teuwen, E.A.H. Lanters, J.M.E. van der Does, E.M.J.P. Mouws, C.A. Houck, R. Starreveld, C.S. Serban and R.K. Kharbanda for their help with acquiring the mapping data, and we would also like to kindly thank the cardiothoracic surgeons J.A. Bekkers, W.J. van Leeuwen, F.B.S. Oei, F.R.N. van Schaagen and P.C. van de Woestijne for their contribution to this work. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

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doi = "10.3390/jcm10235536",

language = "English",

volume = "10",

journal = "Journal of Clinical Medicine",

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T1 - Af inducibility is related to conduction abnormalities at bachmann’s bundle

AU - van Staveren, Lianne N.

AU - van der Does, Willemijn F.B.

AU - Heida, Annejet

AU - Taverne, Yannick J.H.J.

AU - Bogers, Ad J.J.C.

AU - de Groot, Natasja M.S.

N1 - Funding Information: Funding: N.M.S. de Groot is supported by funding grants from CVON‐AFFIP (914728), NWO‐Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS‐331) was conducted with financial support from the Investigator‐Initiated Study Program of Biosense Webster, Inc. Funding Information: N.M.S. de Groot is supported by funding grants from CVON?AFFIP (914728), NWO?Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Delta. This research (IIS?331) was conducted with financial support from the Investigator?Initiated Study Program of Biosense Webster, Inc. The authors would like to kindly thank our colleagues A. Yaksh, C.P. Teuwen, E.A.H. Lanters, J.M.E. van der Does, E.M.J.P. Mouws, C.A. Houck, R. Starreveld, C.S. Serban and R.K. Kharbanda for their help with acquiring the mapping data, and we would also like to kindly thank the cardiothoracic surgeons J.A. Bekkers, W.J. van Leeuwen, F.B.S. Oei, F.R.N. van Schaagen and P.C. van de Woestijne for their contribution to this work. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11/26

Y1 - 2021/11/26

N2 - We investigated whether patterns of activation at Bachmann’s bundle are related to AF inducibility. Epicardial mapping of Bachmann’s bundle during sinus rhythm was performed prior to cardiac surgery (192 electrodes, interelectrode distances: 2 mm). Compared to non‐inducible patients (N = 20), patients with inducible AF (N = 34) had longer lines of conduction block (18(2– 164) mm vs. 6(2–28) mm, p = 0.048), prolonged total activation time (55(28–143) ms vs. 46(24–73) ms, p = 0.012), multiple wavefronts entering Bachmann’s bundle more frequently (64% vs. 37%, p = 0.046) and more often areas of simultaneous activation (conduction velocity > 1.7 m/s, 45% vs. 16%, p = 0.038). These observations further support a relation between conduction abnormalities at Bachmann’s bundle and AF inducibility. The next step is to examine whether Bachmann’s bundle activation patterns can also be used to identify patients who will develop AF after cardiac surgery during both short‐ and long‐term follow‐up.

AB - We investigated whether patterns of activation at Bachmann’s bundle are related to AF inducibility. Epicardial mapping of Bachmann’s bundle during sinus rhythm was performed prior to cardiac surgery (192 electrodes, interelectrode distances: 2 mm). Compared to non‐inducible patients (N = 20), patients with inducible AF (N = 34) had longer lines of conduction block (18(2– 164) mm vs. 6(2–28) mm, p = 0.048), prolonged total activation time (55(28–143) ms vs. 46(24–73) ms, p = 0.012), multiple wavefronts entering Bachmann’s bundle more frequently (64% vs. 37%, p = 0.046) and more often areas of simultaneous activation (conduction velocity > 1.7 m/s, 45% vs. 16%, p = 0.038). These observations further support a relation between conduction abnormalities at Bachmann’s bundle and AF inducibility. The next step is to examine whether Bachmann’s bundle activation patterns can also be used to identify patients who will develop AF after cardiac surgery during both short‐ and long‐term follow‐up.

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U2 - 10.3390/jcm10235536

DO - 10.3390/jcm10235536

M3 - Article

AN - SCOPUS:85119898006

SN - 2077-0383

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 23

M1 - 5536

ER -

Af inducibility is related to conduction abnormalities at bachmann’s bundle

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