Objective To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). Design and patients In this multicentre prospective registry study, 2432 patients (mean age 57 +/- 12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age <60 or >= 60 years and, male or female gender. Main outcome measures A composite end point of cardiac death and non-fatal myocardial infarction. Results CTA results were normal in 991 (41%) patients, showed non-significant CAD in 761 (31%) patients and significant CAD in the remaining 680 (28%) patients. During follow-up (median 819 days, 25=75th centile 482=1142) a cardiovascular event occurred in 59 (2.4%) patients. The annualised event rate was 1.1% in the total population (men=1.3% and women=0.9%). In patients aged <60 years, the annualised event rate of male and female patients was 0.6% and 0.5%, respectively. Among patients aged >= Conclusions After age and gender stratification, CTA findings were shown to be of limited predictive value in female patients aged <60 years as compared with male patients at any age and female patients aged >= 60 years.