Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Mehlika Toy; Fatih Oguz Onder; Tanja Woermann; A. Mithat Bozdayi; Solko W. Schalm; Gerard J. Borsboom; Joost van Rosmalen; Jan Hendrik Richardus; Cihan Yurdaydin

doi:10.1186/1471-2334-11-337

Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Mehlika Toy^*
, Fatih Oguz Onder
, Tanja Woermann
, A. Mithat Bozdayi
, Solko W. Schalm
, Gerard J. Borsboom
, Joost van Rosmalen
, Jan Hendrik Richardus
, Cihan Yurdaydin

^*Corresponding author for this work

Turkey Specialized Higher Education & Research Hospital
Bielefeld University
Ankara University, Ankara, Turkey
LiverDoc, Rotterdam

Research output: Contribution to journal › Article › Academic › peer-review

98 Citations (Web of Science)

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Abstract

BACKGROUND: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.

METHODS: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.

RESULTS: The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.

CONCLUSION: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

Original language	English
Pages (from-to)	337
Number of pages	12
Journal	BMC Infectious Diseases
Volume	11
DOIs	https://doi.org/10.1186/1471-2334-11-337 https://doi.org/10.1186/1471-2334-11-337
Publication status	Published - 12 Dec 2011

Bibliographical note

Source of funding:
This work was supported by the European Association for the Study of the
Liver (EASL) Dame Sheila Sherlock short-term fellowship awarded to Mehlika
Toy.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research programs

EMC NIHES-02-65-01

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http://hdl.handle.net/1765/34331

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Toy, M., Onder, F. O., Woermann, T., Bozdayi, A. M., Schalm, S. W., Borsboom, G. J., van Rosmalen, J., Richardus, J. H., & Yurdaydin, C. (2011). Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review. BMC Infectious Diseases, 11, 337. https://doi.org/10.1186/1471-2334-11-337, https://doi.org/10.1186/1471-2334-11-337

@article{3bd0539a46964be2a82a0df330bb5edc,

title = "Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review",

abstract = "BACKGROUND: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.METHODS: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.RESULTS: The estimated overall population prevalence was 4.57, 95\% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95\% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95\% CI: 5.83, 6.90) in the 25-34-year-old group.CONCLUSION: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.",

author = "Mehlika Toy and Onder, \{Fatih Oguz\} and Tanja Woermann and Bozdayi, \{A. Mithat\} and Schalm, \{Solko W.\} and Borsboom, \{Gerard J.\} and \{van Rosmalen\}, Joost and Richardus, \{Jan Hendrik\} and Cihan Yurdaydin",

note = "Source of funding: This work was supported by the European Association for the Study of the Liver (EASL) Dame Sheila Sherlock short-term fellowship awarded to Mehlika Toy.",

year = "2011",

month = dec,

day = "12",

doi = "10.1186/1471-2334-11-337",

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Toy, M, Onder, FO, Woermann, T, Bozdayi, AM, Schalm, SW, Borsboom, GJ, van Rosmalen, J, Richardus, JH & Yurdaydin, C 2011, 'Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review', BMC Infectious Diseases, vol. 11, pp. 337. https://doi.org/10.1186/1471-2334-11-337, https://doi.org/10.1186/1471-2334-11-337

TY - JOUR

T1 - Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models

T2 - a systematic review

AU - Toy, Mehlika

AU - Onder, Fatih Oguz

AU - Woermann, Tanja

AU - Bozdayi, A. Mithat

AU - Schalm, Solko W.

AU - Borsboom, Gerard J.

AU - van Rosmalen, Joost

AU - Richardus, Jan Hendrik

AU - Yurdaydin, Cihan

N1 - Source of funding: This work was supported by the European Association for the Study of the Liver (EASL) Dame Sheila Sherlock short-term fellowship awarded to Mehlika Toy.

PY - 2011/12/12

Y1 - 2011/12/12

N2 - BACKGROUND: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.METHODS: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.RESULTS: The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.CONCLUSION: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

AB - BACKGROUND: To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.METHODS: A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.RESULTS: The estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-year olds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.CONCLUSION: There are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

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U2 - 10.1186/1471-2334-11-337

DO - 10.1186/1471-2334-11-337

M3 - Article

C2 - 22151620

SN - 1471-2334

VL - 11

SP - 337

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

ER -

Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

Abstract

Bibliographical note

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