Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

R C Slieker; M van Iterson; R Luijk; M Beekman; DV Zhernakova; MH Moed; H L Mei; M van Galen; P Deelen; MJ Bonder; A Zhernakova; André Uitterlinden; E F Tigchelaar; CDA Stehouwer; CG Schalkwijk; CJH van der Kallen; Bert Hofman; D van Heemst; EJ de Geus; J Dongen; J Deelen; LH van den Berg; Joyce van Meurs; R Jansen; PAC 't Hoen; L Franke; C Wijmenga; JH Veldink; MA Swertz; MMJ van Greevenbroek; Cornelia Duijn; DI Boomsma; PE (Eline) Slagboom; BT Heijmans

doi:10.1186/s13059-016-1053-6

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

R C Slieker
, M van Iterson
, R Luijk
, M Beekman
, DV Zhernakova
, MH Moed
, H L Mei
, M van Galen
, P Deelen
, MJ Bonder
, A Zhernakova
, André Uitterlinden
, E F Tigchelaar
, CDA Stehouwer
, CG Schalkwijk
, CJH van der Kallen
, Bert Hofman
, D van Heemst
, EJ de Geus
, J Dongen

J Deelen, LH van den Berg, Joyce van Meurs, R Jansen, PAC 't Hoen, L Franke, C Wijmenga, JH Veldink, MA Swertz, MMJ van Greevenbroek, Cornelia Duijn, DI Boomsma, PE (Eline) Slagboom, BT Heijmans

Research output: Contribution to journal › Article › Academic › peer-review

128 Citations (Scopus)

50 Downloads (Pure)

Original language	English
Article number	191
Journal	Genome Biology
Volume	17
DOIs	https://doi.org/10.1186/s13059-016-1053-6
Publication status	Published - 22 Sept 2016

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-02

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http://hdl.handle.net/1765/93446

Cite this

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, DV., Moed, MH., Mei, H. L., van Galen, M., Deelen, P., Bonder, MJ., Zhernakova, A., Uitterlinden, A., Tigchelaar, E. F., Stehouwer, CDA., Schalkwijk, CG., van der Kallen, CJH., Hofman, B., van Heemst, D., de Geus, EJ., ... Heijmans, BT. (2016). Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology, 17, Article 191. https://doi.org/10.1186/s13059-016-1053-6

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title = "Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms",

author = "Slieker, \{R C\} and \{van Iterson\}, M and R Luijk and M Beekman and DV Zhernakova and MH Moed and Mei, \{H L\} and \{van Galen\}, M and P Deelen and MJ Bonder and A Zhernakova and Andr{\'e} Uitterlinden and Tigchelaar, \{E F\} and CDA Stehouwer and CG Schalkwijk and \{van der Kallen\}, CJH and Bert Hofman and \{van Heemst\}, D and \{de Geus\}, EJ and J Dongen and J Deelen and \{van den Berg\}, LH and \{van Meurs\}, Joyce and R Jansen and \{'t Hoen\}, PAC and L Franke and C Wijmenga and JH Veldink and MA Swertz and \{van Greevenbroek\}, MMJ and Cornelia Duijn and DI Boomsma and Slagboom, \{PE (Eline)\} and BT Heijmans",

year = "2016",

month = sep,

day = "22",

doi = "10.1186/s13059-016-1053-6",

language = "English",

volume = "17",

journal = "Genome Biology",

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Slieker, RC, van Iterson, M, Luijk, R, Beekman, M, Zhernakova, DV, Moed, MH, Mei, HL, van Galen, M, Deelen, P, Bonder, MJ, Zhernakova, A, Uitterlinden, A, Tigchelaar, EF, Stehouwer, CDA, Schalkwijk, CG, van der Kallen, CJH, Hofman, B, van Heemst, D, de Geus, EJ, Dongen, J, Deelen, J, van den Berg, LH, van Meurs, J, Jansen, R, 't Hoen, PAC, Franke, L, Wijmenga, C, Veldink, JH, Swertz, MA, van Greevenbroek, MMJ, Duijn, C, Boomsma, DI, Slagboom, PE & Heijmans, BT 2016, 'Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms', Genome Biology, vol. 17, 191. https://doi.org/10.1186/s13059-016-1053-6

TY - JOUR

T1 - Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

AU - Slieker, R C

AU - van Iterson, M

AU - Luijk, R

AU - Beekman, M

AU - Zhernakova, DV

AU - Moed, MH

AU - Mei, H L

AU - van Galen, M

AU - Deelen, P

AU - Bonder, MJ

AU - Zhernakova, A

AU - Uitterlinden, André

AU - Tigchelaar, E F

AU - Stehouwer, CDA

AU - Schalkwijk, CG

AU - van der Kallen, CJH

AU - Hofman, Bert

AU - van Heemst, D

AU - de Geus, EJ

AU - Dongen, J

AU - Deelen, J

AU - van den Berg, LH

AU - van Meurs, Joyce

AU - Jansen, R

AU - 't Hoen, PAC

AU - Franke, L

AU - Wijmenga, C

AU - Veldink, JH

AU - Swertz, MA

AU - van Greevenbroek, MMJ

AU - Duijn, Cornelia

AU - Boomsma, DI

AU - Slagboom, PE (Eline)

AU - Heijmans, BT

PY - 2016/9/22

Y1 - 2016/9/22

U2 - 10.1186/s13059-016-1053-6

DO - 10.1186/s13059-016-1053-6

M3 - Article

C2 - 27654999

SN - 1474-760X

VL - 17

JO - Genome Biology

JF - Genome Biology

M1 - 191

ER -