Akute Niereninsuffizienz bei der behandlung der Psoriasis mit Fumarsäure-estern

J. I. Roodnat; M. H.L. Christiaans; W. M. Nugteren-Huying; J. G. Van der Schroeff; P. Van der Zouwen; B. H.C. Stricker; J. J. Weening; P. C. Chang

Akute Niereninsuffizienz bei der behandlung der Psoriasis mit Fumarsäure-estern

Translated title of the contribution: Acute renal failure during therapy for psoriasis with fumaric acid-esters

J. I. Roodnat, M. H.L. Christiaans, W. M. Nugteren-Huying, J. G. Van der Schroeff, P. Van der Zouwen, B. H.C. Stricker, J. J. Weening, P. C. Chang

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Abstract

We describe two patients who developed acute renal failure during therapy with fumaric acid-esters. Histologic findings after renal biopsy in one patient were compatible with the diagnosis of acute tubular necrosis (ATN), and renal function was restored after cessation of the medication. The histologic diagnosis in the other patient was tubulo-interstitial nephritis (TIN), possibly reactive to ATN. The recovery of renal function was incomplete after 9 months. Two other patients had deterioration of renal function and proteinuria during therapy with fumaric acid-esters. The symptoms were completely reversible in one patient after discontinuation of the medication, and incompletely reversible in the other. The literature is reviewed and a comparison is drawn with the maleic acid model in the rat.

Translated title of the contribution	Acute renal failure during therapy for psoriasis with fumaric acid-esters
Original language	German
Pages (from-to)	826-830
Number of pages	5
Journal	Schweizerische Medizinische Wochenschrift
Volume	119
Issue number	23
Publication status	Published - 1989
Externally published	Yes

Cite this

@article{06b927cf0c044540910ff6de12c73244,

title = "Akute Niereninsuffizienz bei der behandlung der Psoriasis mit Fumars{\"a}ure-estern",

abstract = "We describe two patients who developed acute renal failure during therapy with fumaric acid-esters. Histologic findings after renal biopsy in one patient were compatible with the diagnosis of acute tubular necrosis (ATN), and renal function was restored after cessation of the medication. The histologic diagnosis in the other patient was tubulo-interstitial nephritis (TIN), possibly reactive to ATN. The recovery of renal function was incomplete after 9 months. Two other patients had deterioration of renal function and proteinuria during therapy with fumaric acid-esters. The symptoms were completely reversible in one patient after discontinuation of the medication, and incompletely reversible in the other. The literature is reviewed and a comparison is drawn with the maleic acid model in the rat.",

author = "Roodnat, \{J. I.\} and Christiaans, \{M. H.L.\} and Nugteren-Huying, \{W. M.\} and \{Van der Schroeff\}, \{J. G.\} and \{Van der Zouwen\}, P. and Stricker, \{B. H.C.\} and Weening, \{J. J.\} and Chang, \{P. C.\}",

year = "1989",

language = "German",

volume = "119",

pages = "826--830",

journal = "Schweizerische Medizinische Wochenschrift",

issn = "0036-7672",

publisher = "SMW supporting association",

number = "23",

}

TY - JOUR

T1 - Akute Niereninsuffizienz bei der behandlung der Psoriasis mit Fumarsäure-estern

AU - Roodnat, J. I.

AU - Christiaans, M. H.L.

AU - Nugteren-Huying, W. M.

AU - Van der Schroeff, J. G.

AU - Van der Zouwen, P.

AU - Stricker, B. H.C.

AU - Weening, J. J.

AU - Chang, P. C.

PY - 1989

Y1 - 1989

N2 - We describe two patients who developed acute renal failure during therapy with fumaric acid-esters. Histologic findings after renal biopsy in one patient were compatible with the diagnosis of acute tubular necrosis (ATN), and renal function was restored after cessation of the medication. The histologic diagnosis in the other patient was tubulo-interstitial nephritis (TIN), possibly reactive to ATN. The recovery of renal function was incomplete after 9 months. Two other patients had deterioration of renal function and proteinuria during therapy with fumaric acid-esters. The symptoms were completely reversible in one patient after discontinuation of the medication, and incompletely reversible in the other. The literature is reviewed and a comparison is drawn with the maleic acid model in the rat.

AB - We describe two patients who developed acute renal failure during therapy with fumaric acid-esters. Histologic findings after renal biopsy in one patient were compatible with the diagnosis of acute tubular necrosis (ATN), and renal function was restored after cessation of the medication. The histologic diagnosis in the other patient was tubulo-interstitial nephritis (TIN), possibly reactive to ATN. The recovery of renal function was incomplete after 9 months. Two other patients had deterioration of renal function and proteinuria during therapy with fumaric acid-esters. The symptoms were completely reversible in one patient after discontinuation of the medication, and incompletely reversible in the other. The literature is reviewed and a comparison is drawn with the maleic acid model in the rat.

UR - https://www.scopus.com/pages/publications/0024308288

M3 - Article

C2 - 2772586

AN - SCOPUS:0024308288

SN - 0036-7672

VL - 119

SP - 826

EP - 830

JO - Schweizerische Medizinische Wochenschrift

JF - Schweizerische Medizinische Wochenschrift

IS - 23

ER -

Akute Niereninsuffizienz bei der behandlung der Psoriasis mit Fumarsäure-estern

Abstract

Other files and links

Fingerprint

Acute nierinsufficiëntie bij patiënten behandeld met fumaarzuuresters wegens psoriasis

Cite this