ALA-PDT of the normal rat oesophagus: Efficiency and safety largely depends on the timing of illumination

JC Boogert - Kluin, Ron de Bruin, HJ Staveren, PD (Peter) Siersema, R (Richard) van Hillegersberg

Research output: Contribution to journalConference articleProfessional

1 Citation (Scopus)

Abstract

200 mg/kg 5-Aminolevulinic acid (ALA) was given orally to 24 rats. Four animals served as controls and received phosphate buffered saline orally. The animals were illuminated at various time points after ALA administration. Illumination was performed with a cylindrical diffuser placed in a balloon catheter. The same illumination parameters (633 nm, 25 J radiant energy/cm diffuser, power output 100 mW/cm diffuser) were used for each animal. During illumination, fluorescent measurements and light dosimetry were performed. The animals were sacrificed at 48 hours after photodynamic therapy for histological assessment.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3563
DOIs
Publication statusPublished - 1999
EventProceedings of the 1998 Photochemotherapy of Cancer and Other Diseases - Stockholm, SWE
Duration: 9 Sept 199811 Sept 1998

Research programs

  • EMC MM-03-47-06-A

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