ALA-PDT of the normal rat oesophagus: Efficiency and safety largely depends on the timing of illumination

JC Boogert - Kluin; Ron de Bruin; HJ Staveren; PD (Peter) Siersema; R (Richard) van Hillegersberg

doi:10.1117/12.339123

ALA-PDT of the normal rat oesophagus: Efficiency and safety largely depends on the timing of illumination

JC Boogert - Kluin
, Ron de Bruin
, HJ Staveren
, PD (Peter) Siersema
, R (Richard) van Hillegersberg

Research output: Contribution to journal › Conference article › Professional

1 Citation (Scopus)

Abstract

200 mg/kg 5-Aminolevulinic acid (ALA) was given orally to 24 rats. Four animals served as controls and received phosphate buffered saline orally. The animals were illuminated at various time points after ALA administration. Illumination was performed with a cylindrical diffuser placed in a balloon catheter. The same illumination parameters (633 nm, 25 J radiant energy/cm diffuser, power output 100 mW/cm diffuser) were used for each animal. During illumination, fluorescent measurements and light dosimetry were performed. The animals were sacrificed at 48 hours after photodynamic therapy for histological assessment.

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3563
DOIs	https://doi.org/10.1117/12.339123
Publication status	Published - 1999
Event	Proceedings of the 1998 Photochemotherapy of Cancer and Other Diseases - Stockholm, SWE Duration: 9 Sept 1998 → 11 Sept 1998

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10.1117/12.339123

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@article{a451cdb1debb4df3a3f689af99ecd8d7,

title = "ALA-PDT of the normal rat oesophagus: Efficiency and safety largely depends on the timing of illumination",

abstract = "200 mg/kg 5-Aminolevulinic acid (ALA) was given orally to 24 rats. Four animals served as controls and received phosphate buffered saline orally. The animals were illuminated at various time points after ALA administration. Illumination was performed with a cylindrical diffuser placed in a balloon catheter. The same illumination parameters (633 nm, 25 J radiant energy/cm diffuser, power output 100 mW/cm diffuser) were used for each animal. During illumination, fluorescent measurements and light dosimetry were performed. The animals were sacrificed at 48 hours after photodynamic therapy for histological assessment.",

author = "\{Boogert - Kluin\}, JC and \{de Bruin\}, Ron and HJ Staveren and Siersema, \{PD (Peter)\} and \{van Hillegersberg\}, \{R (Richard)\}",

year = "1999",

doi = "10.1117/12.339123",

language = "English",

volume = "3563",

pages = "82--88",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE - The International Society for Optical Engineering",

note = "Proceedings of the 1998 Photochemotherapy of Cancer and Other Diseases ; Conference date: 09-09-1998 Through 11-09-1998",

}

TY - JOUR

T1 - ALA-PDT of the normal rat oesophagus

T2 - Proceedings of the 1998 Photochemotherapy of Cancer and Other Diseases

AU - Boogert - Kluin, JC

AU - de Bruin, Ron

AU - Staveren, HJ

AU - Siersema, PD (Peter)

AU - van Hillegersberg, R (Richard)

PY - 1999

Y1 - 1999

N2 - 200 mg/kg 5-Aminolevulinic acid (ALA) was given orally to 24 rats. Four animals served as controls and received phosphate buffered saline orally. The animals were illuminated at various time points after ALA administration. Illumination was performed with a cylindrical diffuser placed in a balloon catheter. The same illumination parameters (633 nm, 25 J radiant energy/cm diffuser, power output 100 mW/cm diffuser) were used for each animal. During illumination, fluorescent measurements and light dosimetry were performed. The animals were sacrificed at 48 hours after photodynamic therapy for histological assessment.

AB - 200 mg/kg 5-Aminolevulinic acid (ALA) was given orally to 24 rats. Four animals served as controls and received phosphate buffered saline orally. The animals were illuminated at various time points after ALA administration. Illumination was performed with a cylindrical diffuser placed in a balloon catheter. The same illumination parameters (633 nm, 25 J radiant energy/cm diffuser, power output 100 mW/cm diffuser) were used for each animal. During illumination, fluorescent measurements and light dosimetry were performed. The animals were sacrificed at 48 hours after photodynamic therapy for histological assessment.

UR - https://www.scopus.com/pages/publications/0032637230

UR - https://ui.adsabs.harvard.edu/abs/1999SPIE.3563...82V/abstract

U2 - 10.1117/12.339123

DO - 10.1117/12.339123

M3 - Conference article

SN - 0277-786X

VL - 3563

SP - 82

EP - 88

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

Y2 - 9 September 1998 through 11 September 1998

ER -

ALA-PDT of the normal rat oesophagus: Efficiency and safety largely depends on the timing of illumination

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