All-cause mortality benefit of coronary revascularization vs. medical therapy in patients without known coronary artery disease undergoing coronary computed tomographic angiography: results from CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)

JK Min, DS Berman, A Dunning, S Achenbach, M Al-Mallah, MJ Budoff, F. Cademartiri, TQ Callister, HJ Chang, V Cheng, K Chinnaiyan, BJW Chow, R Cury, A Delago, G Feuchtner, M Hadamitzky, J Hausleiter, P Kaufmann, RP Karlsberg, YJ KimJ Leipsic, FY Lin, E Maffei, F Plank, G Raff, T Villines, TM Labounty, LJ Shaw

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Abstract

Aims To date, the therapeutic benefit of revascularization vs. medical therapy for stable individuals undergoing invasive coronary angiography (ICA) based upon coronary computed tomographic angiography (CCTA) findings has not been examined. Methods and results We examined 15 223 patients without known coronary artery disease (CAD) undergoing CCTA from eight sites and six countries who were followed for median 2.1 years (interquartile range 1.4-3.3 years) for an endpoint of all-cause mortality. Obstructive CAD by CCTA was defined as a >= 50% luminal diameter stenosis in a major coronary artery. Patients were categorized as having high-risk CAD vs. non-high-risk CAD, with the former including patients with at least obstructive two-ve Conclusion In an intermediate-term follow-up, coronary revascularization is associated with a survival benefit in patients with high-risk CAD by CCTA, with no apparent benefit of revascularization in patients with lesser forms of CAD.
Original languageUndefined/Unknown
Pages (from-to)3088-3097
Number of pages10
JournalEuropean Heart Journal
Volume33
Issue number24
DOIs
Publication statusPublished - 2012

Research programs

  • EMC NIHES-03-30-01

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