TY - JOUR
T1 - AMH in PCOS
T2 - Controlling the ovary, placenta, or brain?
AU - Moolhuijsen, Loes M.E.
AU - Visser, Jenny A.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/6
Y1 - 2020/6
N2 - Polycystic ovary syndrome (PCOS) is a very heterogeneous disease of which the exact pathophysiological mechanisms remain unknown. In PCOS, serum anti-Müllerian hormone (AMH) levels are significantly increased. AMH is a member of the transforming growth factor β family and is expressed by growing follicles in the ovaries. In PCOS, the transcriptional regulation of AMH and AMHR2 is altered, increasing and prolonging its temporal expression pattern. Moreover, the recently discovered extragonadal effects of AMH suggest that there might be a crosstalk between the ovary–placenta–brain. This review summarizes the recent findings concerning AMH and its role in the etiology of PCOS.
AB - Polycystic ovary syndrome (PCOS) is a very heterogeneous disease of which the exact pathophysiological mechanisms remain unknown. In PCOS, serum anti-Müllerian hormone (AMH) levels are significantly increased. AMH is a member of the transforming growth factor β family and is expressed by growing follicles in the ovaries. In PCOS, the transcriptional regulation of AMH and AMHR2 is altered, increasing and prolonging its temporal expression pattern. Moreover, the recently discovered extragonadal effects of AMH suggest that there might be a crosstalk between the ovary–placenta–brain. This review summarizes the recent findings concerning AMH and its role in the etiology of PCOS.
UR - http://www.scopus.com/inward/record.url?scp=85085189382&partnerID=8YFLogxK
U2 - 10.1016/j.coemr.2020.04.006
DO - 10.1016/j.coemr.2020.04.006
M3 - Review article
AN - SCOPUS:85085189382
SN - 2451-9650
VL - 12
SP - 91
EP - 97
JO - Current Opinion in Endocrine and Metabolic Research
JF - Current Opinion in Endocrine and Metabolic Research
ER -
