AMH in PCOS: Controlling the ovary, placenta, or brain?

Loes M.E. Moolhuijsen, Jenny A. Visser*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
18 Downloads (Pure)

Abstract

Polycystic ovary syndrome (PCOS) is a very heterogeneous disease of which the exact pathophysiological mechanisms remain unknown. In PCOS, serum anti-Müllerian hormone (AMH) levels are significantly increased. AMH is a member of the transforming growth factor β family and is expressed by growing follicles in the ovaries. In PCOS, the transcriptional regulation of AMH and AMHR2 is altered, increasing and prolonging its temporal expression pattern. Moreover, the recently discovered extragonadal effects of AMH suggest that there might be a crosstalk between the ovary–placenta–brain. This review summarizes the recent findings concerning AMH and its role in the etiology of PCOS.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalCurrent Opinion in Endocrine and Metabolic Research
Volume12
DOIs
Publication statusPublished - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

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