TY - JOUR
T1 - Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume
AU - Sánchez-Benavides, Gonzalo
AU - Suárez-Calvet, Marc
AU - Milà-Alomà, Marta
AU - Arenaza-Urquijo, Eider M.
AU - Grau-Rivera, Oriol
AU - Operto, Grégory
AU - Gispert, Juan Domingo
AU - Vilor-Tejedor, Natalia
AU - Sala-Vila, Aleix
AU - Crous-Bou, Marta
AU - González-de-Echávarri, José Maria
AU - Minguillon, Carolina
AU - Fauria, Karine
AU - Simon, Maryline
AU - Kollmorgen, Gwendlyn
AU - Zetterberg, Henrik
AU - Blennow, Kaj
AU - Molinuevo, José Luis
N1 - Publisher Copyright:
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-β (Aβ) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Linear models accounting for covariates (age, gender, and mood) were used to test the association between CSF NfL and SCD status, and between CSF NfL and bilateral hippocampal volumes. Interactions with Aβ were also explored. Individuals with SCD had higher CSF NfL and lower CSF Aβ42/40 than Controls. There was a significant interaction between SCD and CSF-Aβ42/40 levels. Stratified analyses showed a significant association between SCD and NfL only in Aβ+ individuals. Higher CSF NfL was significantly associated with lower hippocampal volume specifically in Aβ+ individuals with SCD. The presence of SCD in Aβ+ individuals may represent an early symptom in the Alzheimer's continuum related to incipient neurodegeneration.
AB - Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-β (Aβ) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Linear models accounting for covariates (age, gender, and mood) were used to test the association between CSF NfL and SCD status, and between CSF NfL and bilateral hippocampal volumes. Interactions with Aβ were also explored. Individuals with SCD had higher CSF NfL and lower CSF Aβ42/40 than Controls. There was a significant interaction between SCD and CSF-Aβ42/40 levels. Stratified analyses showed a significant association between SCD and NfL only in Aβ+ individuals. Higher CSF NfL was significantly associated with lower hippocampal volume specifically in Aβ+ individuals with SCD. The presence of SCD in Aβ+ individuals may represent an early symptom in the Alzheimer's continuum related to incipient neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=85109354586&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2021.02.026
DO - 10.1016/j.neurobiolaging.2021.02.026
M3 - Article
C2 - 33962331
AN - SCOPUS:85109354586
SN - 0197-4580
VL - 104
SP - 24
EP - 31
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -