An automated approach to quantify volumetric coronary plaque composition by multi-slice computed tomography: An ex-vivo feasibility study

N. Bruining*, S. Verheye, M. Knaapen, P. Somers, E. Regar, J. Ligthart, F. Cademartiri, S. De Winter, G. Van Langenhove, P. W.J.C. Serruys, P. J. De Feijter, R. Hamers

*Corresponding author for this work

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

Abstract

This study explores the possibility to use the Hounsfield unit (HU) distribution of a coronary plaque to quantify its composition when imaged with multi-slice computed tomography (MSCT). Explanted left anterior descending specimens were imaged with different contrast strengths. In one specimen, 5 sections of 0.9 to 1.4 mm long were 3D-quantitatively evaluated against quantitative volumetric histopathology. There were no substantial differences found between the two quantitative methodologies. Both quantitative methodologies showed a remarkable positive correlation. This ex-vivo multi-modality imaging study shows encouraging results for quantitative MSCT-CA based plaque composition measurements compared against quantitative histopathology.

Original languageEnglish
Title of host publicationComputers in Cardiology 2008, CAR
Pages541-544
Number of pages4
DOIs
Publication statusPublished - Sept 2008
EventComputers in Cardiology 2008, CAR - Bologna, Italy
Duration: 14 Sept 200817 Sept 2008

Publication series

SeriesComputers in Cardiology
Volume35
ISSN0276-6574

Conference

ConferenceComputers in Cardiology 2008, CAR
Country/TerritoryItaly
CityBologna
Period14/09/0817/09/08

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