An ethical framework for human embryology with embryo models

Nicolas C. Rivron; Alfonso Martinez Arias; Martin F. Pera; Naomi Moris; Hafez Ismaili M'hamdi

doi:10.1016/j.cell.2023.07.028

An ethical framework for human embryology with embryo models

Nicolas C. Rivron^*
, Alfonso Martinez Arias
, Martin F. Pera
, Naomi Moris
, Hafez Ismaili M'hamdi

^*Corresponding author for this work

Medical Informatics

Institute of Molecular Biotechnology
Pompeu Fabra University
Jackson Laboratory
The Francis Crick Institute

Research output: Contribution to journal › Review article › Academic › peer-review

77 Citations (Scopus)

348 Downloads (Pure)

Abstract

A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest “tipping points” for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.

Original language	English
Pages (from-to)	3548-3557
Number of pages	10
Journal	Cell
Volume	186
Issue number	17
DOIs	https://doi.org/10.1016/j.cell.2023.07.028
Publication status	Published - 17 Aug 2023

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© 2023 The Author(s)

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AU - Pera, Martin F.

AU - Moris, Naomi

AU - M'hamdi, Hafez Ismaili

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AB - A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest “tipping points” for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.

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ER -

An ethical framework for human embryology with embryo models

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