An in silico trials platform for the evaluation of stent design effect in post-implantation outcomes

Georgia S. Karanasiou, Panagiota I. Tsompou, Nikolaos Tachos, Gianna E. Karanasiou, Antonis Sakellarios, Savvas Kyriakidis, Luca Antonini, Giancarlo Pennati, Lorenza Petrini, Frank Gijsen, Ted Vaughan, Christos Katsouras, Lampros Michalis, Dimitrios I. Fotiadis

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

1 Citation (Scopus)

Abstract

Bioresorbable Vascular Scaffolds (BVS), developed to allow drug deliver and mechanical support, followed by complete resorption, have revolutionized atherosclerosis treatment. InSilc is a Cloud platform for in silico clinical trials (ISCT) used in the design, development and evaluation pipeline of stents. The platform integrates beyond the state-of-the-art multi-disciplinary and multiscale models, which predict the scaffold's performance in the short/acute and medium/long term. In this study, a use case scenario of two Bioabsorbable Vascular Stents (BVSs) implanted in the same arterial anatomy is presented, allowing the whole InSilc in silico pipeline to be applied and predict how the different aspects of this intervention affect the success of stenting process.

Original languageEnglish
Title of host publication44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4970-4973
Number of pages4
ISBN (Electronic)9781728127828
DOIs
Publication statusPublished - 8 Sept 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022

Publication series

SeriesProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2022-July
ISSN1557-170X

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/2215/07/22

Bibliographical note

Funding Information: Research supported by the InSilc project that has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 777119.

Publisher Copyright: © 2022 IEEE.

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