An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Elshad Hasanov; Debra Nana Yeboa; Mathew D. Tucker; Todd A. Swanson; Thomas Hendrix Beckham; Brian Rini; Chibawanye I. Ene; Merve Hasanov; Sophie Derks; Marion Smits; Shaan Dudani; Daniel Y.C. Heng; Priscilla K. Brastianos; Axel Bex; Sahin Hanalioglu; Jeffrey S. Weinberg; Laure Hirsch; Maria I. Carlo; Ayal Aizer; Paul David Brown; Mehmet Asim Bilen; Eric Lin Chang; Jerry Jaboin; James Brugarolas; Toni K. Choueiri; Michael B. Atkins; Bradley A. McGregor; Lia M. Halasz; Toral R. Patel; Scott G. Soltys; David F. McDermott; James Bradley Elder; Mustafa K. Baskaya; James B. Yu; Robert Timmerman; Michelle Miran Kim; Melike Mut; James Markert; Kathryn Beal; Nizar M. Tannir; George Samandouras; Frederick F. Lang; Rachel Giles; Eric Jonasch

doi:10.3322/caac.21729

An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Elshad Hasanov, Debra Nana Yeboa, Mathew D. Tucker, Todd A. Swanson, Thomas Hendrix Beckham, Brian Rini, Chibawanye I. Ene, Merve Hasanov, Sophie Derks, Marion Smits, Shaan Dudani, Daniel Y.C. Heng, Priscilla K. Brastianos, Axel Bex, Sahin Hanalioglu, Jeffrey S. Weinberg, Laure Hirsch, Maria I. Carlo, Ayal Aizer, Paul David BrownMehmet Asim Bilen, Eric Lin Chang, Jerry Jaboin, James Brugarolas, Toni K. Choueiri, Michael B. Atkins, Bradley A. McGregor, Lia M. Halasz, Toral R. Patel, Scott G. Soltys, David F. McDermott, James Bradley Elder, Mustafa K. Baskaya, James B. Yu, Robert Timmerman, Michelle Miran Kim, Melike Mut, James Markert, Kathryn Beal, Nizar M. Tannir, George Samandouras, Frederick F. Lang, Rachel Giles, Eric Jonasch^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

20 Citations (Scopus)

Abstract

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.

Original language	English
Pages (from-to)	454-489
Number of pages	36
Journal	CA Cancer Journal for Clinicians
Volume	72
Issue number	5
DOIs	https://doi.org/10.3322/caac.21729
Publication status	Published - Sept 2022

Bibliographical note

Acknowledgements: We thank the International Kidney Cancer Coalition for supporting this consensus- building task force. We thank Sunita Patterson, Senior Scientific Editor, Research Medical Library, The University of Texas MD Anderson Cancer Center, for editing this article.

Publisher Copyright:
© 2022 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.

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Hasanov, E., Yeboa, D. N., Tucker, M. D., Swanson, T. A., Beckham, T. H., Rini, B., Ene, C. I., Hasanov, M., Derks, S., Smits, M., Dudani, S., Heng, D. Y. C., Brastianos, P. K., Bex, A., Hanalioglu, S., Weinberg, J. S., Hirsch, L., Carlo, M. I., Aizer, A., ... Jonasch, E. (2022). An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma. CA Cancer Journal for Clinicians, 72(5), 454-489. https://doi.org/10.3322/caac.21729

@article{5963c52ea09442a598c1365bb7d69255,

title = "An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma",

abstract = "Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.",

author = "Elshad Hasanov and Yeboa, {Debra Nana} and Tucker, {Mathew D.} and Swanson, {Todd A.} and Beckham, {Thomas Hendrix} and Brian Rini and Ene, {Chibawanye I.} and Merve Hasanov and Sophie Derks and Marion Smits and Shaan Dudani and Heng, {Daniel Y.C.} and Brastianos, {Priscilla K.} and Axel Bex and Sahin Hanalioglu and Weinberg, {Jeffrey S.} and Laure Hirsch and Carlo, {Maria I.} and Ayal Aizer and Brown, {Paul David} and Bilen, {Mehmet Asim} and Chang, {Eric Lin} and Jerry Jaboin and James Brugarolas and Choueiri, {Toni K.} and Atkins, {Michael B.} and McGregor, {Bradley A.} and Halasz, {Lia M.} and Patel, {Toral R.} and Soltys, {Scott G.} and McDermott, {David F.} and Elder, {James Bradley} and Baskaya, {Mustafa K.} and Yu, {James B.} and Robert Timmerman and Kim, {Michelle Miran} and Melike Mut and James Markert and Kathryn Beal and Tannir, {Nizar M.} and George Samandouras and Lang, {Frederick F.} and Rachel Giles and Eric Jonasch",

note = "Acknowledgements: We thank the International Kidney Cancer Coalition for supporting this consensus- building task force. We thank Sunita Patterson, Senior Scientific Editor, Research Medical Library, The University of Texas MD Anderson Cancer Center, for editing this article. Publisher Copyright: {\textcopyright} 2022 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.",

year = "2022",

month = sep,

doi = "10.3322/caac.21729",

language = "English",

volume = "72",

pages = "454--489",

journal = "CA Cancer Journal for Clinicians",

issn = "0007-9235",

publisher = "Wiley-Blackwell",

number = "5",

}

Hasanov, E, Yeboa, DN, Tucker, MD, Swanson, TA, Beckham, TH, Rini, B, Ene, CI, Hasanov, M, Derks, S , Smits, M, Dudani, S, Heng, DYC, Brastianos, PK, Bex, A, Hanalioglu, S, Weinberg, JS, Hirsch, L, Carlo, MI, Aizer, A, Brown, PD, Bilen, MA, Chang, EL, Jaboin, J, Brugarolas, J, Choueiri, TK, Atkins, MB, McGregor, BA, Halasz, LM, Patel, TR, Soltys, SG, McDermott, DF, Elder, JB, Baskaya, MK, Yu, JB, Timmerman, R, Kim, MM, Mut, M, Markert, J, Beal, K, Tannir, NM, Samandouras, G, Lang, FF, Giles, R & Jonasch, E 2022, 'An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma', CA Cancer Journal for Clinicians, vol. 72, no. 5, pp. 454-489. https://doi.org/10.3322/caac.21729

TY - JOUR

T1 - An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

AU - Hasanov, Elshad

AU - Yeboa, Debra Nana

AU - Tucker, Mathew D.

AU - Swanson, Todd A.

AU - Beckham, Thomas Hendrix

AU - Rini, Brian

AU - Ene, Chibawanye I.

AU - Hasanov, Merve

AU - Derks, Sophie

AU - Smits, Marion

AU - Dudani, Shaan

AU - Heng, Daniel Y.C.

AU - Brastianos, Priscilla K.

AU - Bex, Axel

AU - Hanalioglu, Sahin

AU - Weinberg, Jeffrey S.

AU - Hirsch, Laure

AU - Carlo, Maria I.

AU - Aizer, Ayal

AU - Brown, Paul David

AU - Bilen, Mehmet Asim

AU - Chang, Eric Lin

AU - Jaboin, Jerry

AU - Brugarolas, James

AU - Choueiri, Toni K.

AU - Atkins, Michael B.

AU - McGregor, Bradley A.

AU - Halasz, Lia M.

AU - Patel, Toral R.

AU - Soltys, Scott G.

AU - McDermott, David F.

AU - Elder, James Bradley

AU - Baskaya, Mustafa K.

AU - Yu, James B.

AU - Timmerman, Robert

AU - Kim, Michelle Miran

AU - Mut, Melike

AU - Markert, James

AU - Beal, Kathryn

AU - Tannir, Nizar M.

AU - Samandouras, George

AU - Lang, Frederick F.

AU - Giles, Rachel

AU - Jonasch, Eric

N1 - Acknowledgements: We thank the International Kidney Cancer Coalition for supporting this consensus- building task force. We thank Sunita Patterson, Senior Scientific Editor, Research Medical Library, The University of Texas MD Anderson Cancer Center, for editing this article. Publisher Copyright: © 2022 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.

PY - 2022/9

Y1 - 2022/9

N2 - Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.

AB - Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.

UR - http://www.scopus.com/inward/record.url?scp=85131913351&partnerID=8YFLogxK

U2 - 10.3322/caac.21729

DO - 10.3322/caac.21729

M3 - Review article

C2 - 35708940

AN - SCOPUS:85131913351

SN - 0007-9235

VL - 72

SP - 454

EP - 489

JO - CA Cancer Journal for Clinicians

JF - CA Cancer Journal for Clinicians

IS - 5

ER -

An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Abstract

Bibliographical note

UN SDGs

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