An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft

Eric K.W. Poon, Masafumi Ono, Xinlei Wu, Jouke Dijkstra, Yu Sato, Matthew Kutyna, Ryo Torii, Johan H.C. Reiber, Christos V. Bourantas, Peter Barlis, Mohammed S. El-Kurdi, Martijn Cox, Renu Virmani, Yoshinobu Onuma, Patrick W. Serruys*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Endothelial shear stress (ESS) plays a key role in the clinical outcomes in native and stented segments; however, their implications in bypass grafts and especially in a synthetic biorestorative coronary artery bypass graft are yet unclear. This report aims to examine the interplay between ESS and the morphological alterations of a biorestorative coronary bypass graft in an animal model. Computational fluid dynamics (CFD) simulation derived from the fusion of angiography and optical coherence tomography (OCT) imaging was used to reconstruct data on the luminal anatomy of a bioresorbable coronary bypass graft with an endoluminal “flap” identified during OCT acquisition. The “flap” compromised the smooth lumen surface and considerably disturbed the local flow, leading to abnormally low ESS and high oscillatory shear stress (OSI) in the vicinity of the “flap”. In the presence of the catheter, the flow is more stable (median OSI 0.02384 versus 0.02635, p < 0.0001; maximum OSI 0.4612 versus 0.4837). Conversely, OSI increased as the catheter was withdrawn which can potentially cause back-and-forth motions of the “flap”, triggering tissue fatigue failure. CFD analysis in this report provided sophisticated physiological information that complements the anatomic assessment from imaging enabling a complete understanding of biorestorative graft pathophysiology.

Original languageEnglish
Article number2941
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - 20 Feb 2023

Bibliographical note

Funding Information:
This study was funded by Natural Science Foundation of Zhejiang Province (Grant No. LQ20H180004).

Publisher Copyright:
© 2023, The Author(s).

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