An overview of diagnosis and management of drug-induced hypomagnesemia

George Liamis, Ewout J. Hoorn, Matilda Florentin*, Haralampos Milionis

*Corresponding author for this work

Research output: Contribution to journalReview articleProfessionalpeer-review

4 Citations (Scopus)

Abstract

Magnesium (Mg) is commonly addressed as the “forgotten ion” in medicine. Nonetheless, hypomagnesemia should be suspected in clinical practice in patients with relevant symptomatology and also be considered a predisposing factor for the development of other electrolyte disturbances. Furthermore, chronic hypomagnesemia has been associated with diabetes mellitus and cardiovascular disease. Hypomagnesemia as a consequence of drug therapy is relatively common, with the list of drugs inducing low serum Mg levels expanding. Culprit medications linked to hypomagnesemia include antibiotics (e.g. aminoglycosides, amphotericin B), diuretics, antineoplastic drugs (cisplatin and cetuximab), calcineurin inhibitors, and proton pump inhibitors. In recent years, the mechanisms of drug-induced hypomagnesemia have been unraveled through the discovery of key Mg transporters in the gut and kidney. This narrative review of available literature focuses on the pathogenetic mechanisms underlying drug-induced hypomagnesemia in order to increase the insight of clinicians toward early diagnosis and effective management.

Original languageEnglish
Article numbere00829
JournalPharmacology Research and Perspectives
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Aug 2021

Bibliographical note

Funding Information:
None declared. None declared.

Publisher Copyright:
© 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.

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