TY - JOUR
T1 - An Overview of Liver Directed Locoregional Therapies
AU - Höppener, Diederik J
AU - Grünhagen, Dirk J
AU - Eggermont, Alexander M M
AU - van der Veldt, Astrid A M
AU - Verhoef, Cornelis
N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.
AB - An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.
UR - http://www.scopus.com/inward/record.url?scp=85096500625&partnerID=8YFLogxK
U2 - 10.1016/j.soc.2020.09.001
DO - 10.1016/j.soc.2020.09.001
M3 - Article
C2 - 33220800
SN - 1055-3207
VL - 30
SP - 103
EP - 123
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 1
ER -