An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity

Emma Chang-Rabley, Menno C. van Zelm, Emily E. Ricotta*, Emily S.J. Edwards*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The SARS-CoV-2 pandemic has heightened concerns about immunological protection, especially for individuals with inborn errors of immunity (IEI). While COVID-19 vaccines elicit strong immune responses in healthy individuals, their effectiveness in IEI patients remains unclear, particularly against new viral variants and vaccine formulations. This uncertainty has led to anxiety, prolonged self-isolation, and repeated vaccinations with uncertain benefits among IEI patients. Despite some level of immune response from vaccination, the definition of protective immunity in IEI individuals is still unknown. Given their susceptibility to severe COVID-19, strategies such as immunoglobulin replacement therapy (IgRT) and monoclonal antibodies have been employed to provide passive immunity, and protection against both current and emerging variants. This review examines the efficacy of COVID-19 vaccines and antibody-based therapies in IEI patients, their capacity to recognize viral variants, and the necessary advances required for the ongoing protection of people with IEIs.

Original languageEnglish
Article number675
JournalVaccines
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2024

Bibliographical note

Publisher Copyright: © 2024 by the authors.

Fingerprint

Dive into the research topics of 'An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity'. Together they form a unique fingerprint.

Cite this