An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Bernd Kasper; C. Baumgarten; on behalf of the Desmoid Working Group; J. Garcia; S. Bonvalot; R. Haas; F. Haller; P. Hohenberger; N. Penel; C. Messiou; W. T. van der Graaf; Alessandro Gronchi; S. Bauer; L. H. Lindner; K. Verhoef

doi:10.1093/annonc/mdx323

An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Bernd Kasper^*, C. Baumgarten, on behalf of the Desmoid Working Group, J. Garcia, S. Bonvalot, R. Haas, F. Haller, P. Hohenberger, N. Penel, C. Messiou, W. T. van der Graaf, Alessandro Gronchi^*, S. Bauer, L. H. Lindner, K. Verhoef

^*Corresponding author for this work

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Abstract

Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Currently, there is no established or evidence-based treatment approach available for this disease. Therefore, in 2015 the European Desmoid Working Group published a position paper giving recommendations on the treatment of this intriguing disease. Here, we present an update of this consensus approach based on professionals' AND patients' expertise following a round table meeting bringing together sarcoma experts from the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group with patients and patient advocates from Sarcoma PAtients EuroNet. In this paper, we focus on new findings regarding the prognostic value of mutational analysis in desmoid-type fibromatosis patients and new systemic treatment options.

Original language	English
Pages (from-to)	2399-2408
Number of pages	10
Journal	Annals of Oncology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1093/annonc/mdx323
Publication status	Published - Oct 2017

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© The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

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Kasper, B., Baumgarten, C., on behalf of the Desmoid Working Group, Garcia, J., Bonvalot, S., Haas, R., Haller, F., Hohenberger, P., Penel, N., Messiou, C., van der Graaf, W. T., Gronchi, A., Bauer, S., Lindner, L. H., & Verhoef, K. (2017). An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG). Annals of Oncology, 28(10), 2399-2408. https://doi.org/10.1093/annonc/mdx323

Kasper, Bernd ; Baumgarten, C. ; on behalf of the Desmoid Working Group et al. / An update on the management of sporadic desmoid-type fibromatosis : A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG). In: Annals of Oncology. 2017 ; Vol. 28, No. 10. pp. 2399-2408.

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title = "An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)",

abstract = "Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Currently, there is no established or evidence-based treatment approach available for this disease. Therefore, in 2015 the European Desmoid Working Group published a position paper giving recommendations on the treatment of this intriguing disease. Here, we present an update of this consensus approach based on professionals' AND patients' expertise following a round table meeting bringing together sarcoma experts from the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group with patients and patient advocates from Sarcoma PAtients EuroNet. In this paper, we focus on new findings regarding the prognostic value of mutational analysis in desmoid-type fibromatosis patients and new systemic treatment options.",

author = "Bernd Kasper and C. Baumgarten and {on behalf of the Desmoid Working Group} and J. Garcia and S. Bonvalot and R. Haas and F. Haller and P. Hohenberger and N. Penel and C. Messiou and {van der Graaf}, {W. T.} and Alessandro Gronchi and S. Bauer and Blay, {J. Y.} and {van Coevorden}, F. and P. Dileo and D{\"u}rr, {H. R.} and M. Fiore and V. Gr{\"u}nwald and R. Jones and I. Judson and C. Kettelhack and K. Kopeckova and A. Lazar and Lindner, {L. H.} and J. Martin-Broto and P. Rutkowski and S. Stacchiotti and E. Stoeckle and C. Valverde and K. Verhoef and E. Wardelmann and M. Wartenberg",

year = "2017",

month = oct,

doi = "10.1093/annonc/mdx323",

language = "English",

volume = "28",

pages = "2399--2408",

journal = "Annals of Oncology",

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Kasper, B, Baumgarten, C, on behalf of the Desmoid Working Group, Garcia, J, Bonvalot, S, Haas, R, Haller, F, Hohenberger, P, Penel, N, Messiou, C, van der Graaf, WT, Gronchi, A, Bauer, S, Lindner, LH & Verhoef, K 2017, 'An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)', Annals of Oncology, vol. 28, no. 10, pp. 2399-2408. https://doi.org/10.1093/annonc/mdx323

An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG). / Kasper, Bernd; Baumgarten, C.; on behalf of the Desmoid Working Group et al.
In: Annals of Oncology, Vol. 28, No. 10, 10.2017, p. 2399-2408.

Research output: Contribution to journal › Review article › Popular

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T1 - An update on the management of sporadic desmoid-type fibromatosis

T2 - A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

AU - Kasper, Bernd

AU - Baumgarten, C.

AU - on behalf of the Desmoid Working Group

AU - Garcia, J.

AU - Bonvalot, S.

AU - Haas, R.

AU - Haller, F.

AU - Hohenberger, P.

AU - Penel, N.

AU - Messiou, C.

AU - van der Graaf, W. T.

AU - Gronchi, Alessandro

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AU - Blay, J. Y.

AU - van Coevorden, F.

AU - Dileo, P.

AU - Dürr, H. R.

AU - Fiore, M.

AU - Grünwald, V.

AU - Jones, R.

AU - Judson, I.

AU - Kettelhack, C.

AU - Kopeckova, K.

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AU - Lindner, L. H.

AU - Martin-Broto, J.

AU - Rutkowski, P.

AU - Stacchiotti, S.

AU - Stoeckle, E.

AU - Valverde, C.

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AU - Wardelmann, E.

AU - Wartenberg, M.

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AB - Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Currently, there is no established or evidence-based treatment approach available for this disease. Therefore, in 2015 the European Desmoid Working Group published a position paper giving recommendations on the treatment of this intriguing disease. Here, we present an update of this consensus approach based on professionals' AND patients' expertise following a round table meeting bringing together sarcoma experts from the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group with patients and patient advocates from Sarcoma PAtients EuroNet. In this paper, we focus on new findings regarding the prognostic value of mutational analysis in desmoid-type fibromatosis patients and new systemic treatment options.

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Kasper B, Baumgarten C, on behalf of the Desmoid Working Group, Garcia J, Bonvalot S, Haas R et al. An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG). Annals of Oncology. 2017 Oct;28(10):2399-2408. doi: 10.1093/annonc/mdx323

An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Abstract

Bibliographical note

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