Analysis of biomolecular dynamics by FRAP and computer simulation

Bart Geverts; Martin E. Van Royen; Adriaan B. Houtsmuller

doi:10.1007/978-1-4939-2080-8_7

Analysis of biomolecular dynamics by FRAP and computer simulation

Pathology

Josephine Nefkens Institute (Rotterdam)
Erasmus MC Optical Imaging Center

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

We present a Monte Carlo simulation environment for modelling complex biological molecular interaction networks and for the design, validation, and quantitative analysis of FRAP assays to study these. The program is straightforward in its implementation and can be instructed through an intuitive script language. The simulation tool fi ts very well in a systems biology research setting that aims to maintain an interactive cycle of experiment-driven modelling and model-driven experimentation: the model and the experiment are in the same simulation. The full program can be obtained by request to the authors.

Original language	English
Pages (from-to)	109-133
Number of pages	25
Journal	Methods in Molecular Biology
Volume	1251
DOIs	https://doi.org/10.1007/978-1-4939-2080-8_7
Publication status	Published - 30 Oct 2014

Bibliographical note

Publisher Copyright: © Springer Science+Business Media New York 2015.

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EMC MM-03-24-01

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10.1007/978-1-4939-2080-8_7

Cite this

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Analysis of biomolecular dynamics by FRAP and computer simulation

Abstract

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