Analysis of Worm Burden Variation in Human Schistosoma mansoni Infections by Determination of Serum Levels of Circulating Anodic Antigen and Circulating Cathodic Antigen

Lisette Van Lieshout*, Anton M. Polderman, Sake J. De Vlas, Paul De Caluwé, Frederik W. Krijger, Bruno Gryseels, André M. Deelder

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Abstract

Serum circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) concentrations, as a possible direct measure of worm burden, were compared with fecal egg counts in a heavily Schistosoma mansoni-infected population from Zaire to allow differentiation between worm loads and worm fecundity in relation to age and intensity of infection. Of the 517 subjects, 95% excreted eggs and 97% demonstrated circulating antigens. Fecal egg counts showed an age-related pattern characteristic for an area in which schistosomiasis is endemic with intense transmission levels. Regression analysis showed that antigen concentrations were strongly associated with egg counts. For CAA, but not for CCA, this relation was found to be nonlinear, which would be consistent with density-dependent fecundity or crowding. The trend was uniform for all age groups, which for this particular population indicated a genuine reduction of worm loads rather than reduced worm fecundity with age of the host.

Original languageEnglish
Pages (from-to)1336-1342
Number of pages7
JournalJournal of Infectious Diseases
Volume172
Issue number5
DOIs
Publication statusPublished - Nov 1995
Externally publishedYes

Bibliographical note

© 1995 by The University of Chicago

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