Analyzing the immunogenicity of bivalent booster vaccinations in healthcare workers: The SWITCH ON trial protocol

Wendy Tan, Roos Sablerolles, Wim Rietdijk, Abraham Goorhuis, Douwe F Postma, Leo G. Visser, Susanne Bogers, Daryl Geers, Luca M. Zaeck, Marion Koopmans, V.A.S.H. Dalm, Neeltje A. Kootstra, Anke L.W. Huckriede, Debbie van Baarle, Melvin Lafeber, Corine Geurts van Kessel, Rory de Vries, Hugo van der Kuy*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Vaccination against coronavirus disease 2019 (COVID-19) has contributed greatly to providing protection against severe disease, thereby reducing hospital admissions and deaths. Several studies have reported reduction in vaccine effectiveness over time against the Omicron sub-lineages. However, the willingness to receive regular booster doses in the general population is declining. To determine the need for repeated booster vaccinations in healthy individuals and to aid policymakers in future public health interventions for COVID-19, we aim to gain insight into the immunogenicity of the additional bivalent booster vaccination in a representative sample of the healthy Dutch population. The SWITCH ON study was initiated to investigate three main topics: i) immunogenicity of bivalent vaccines after priming with adenovirus- or mRNA-based vaccines, ii) immunological recall responses and reactivity with relevant variants after booster vaccination, and iii) the necessity of booster vaccinations for the healthy population in the future. Clinical trial registration:, identifier NCT05471440.

Original languageEnglish
Article number1067749
JournalFrontiers in Immunology
Publication statusPublished - 29 Nov 2022

Bibliographical note

Funding Information:
The trial is funded by Netherlands Organization for Health Research and Development ZonMw in the COVID-19 Vaccine program (project grant number: 10430072110001).

Publisher Copyright:
Copyright © 2022 Tan, Sablerolles, Rietdijk, Goorhuis, Postma, Visser, Bogers, Geers, Zaeck, Koopmans, Dalm, Kootstra, Huckriede, van Baarle, Lafeber, GeurtsvanKessel, de Vries and van der Kuy.


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