Anaplasma phagocytophilum from Rodents and Sheep, China

L Zhan, W-C Cao, JF Jiang, XA Zhang, YX (Yun Xi) Liu, XM Wu, WY Zhang, PH Zhang, CL Bian, JS Dumler, H Yang, SQ Zuo, CY Chu, W (Wei) Liu, Jan hendrik Richardus, Dik Habbema

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)


To characterize the strains of Anaplasma phagocytophilum in wild and domestic animals in China, we isolated the organism from rodents and sheep in northeastern China. We isolated 3 strains (2 from rodents and 1 from sick sheep) through propagation in BALB/c mice and then cell culture in HL60 cells. The 3 isolates were identified by Wright-Giemsa staining, immunofluorescence, and electronic microscopy and were characterized by sequence analyses of the 16S rRNA gene, partial citrate synthase gene, major surface protein 4 gene, and heat shock protein gene. The multiple sequences of the 3 isolates were identical to each other but different from all known strains from other countries. The public health and veterinary relevance of the isolates deserves further investigation.
Original languageUndefined/Unknown
Pages (from-to)764-768
Number of pages5
JournalEmerging Infectious Diseases
Issue number5
Publication statusPublished - 2010

Cite this