Abstract
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
Original language | English |
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Pages (from-to) | 270-272 |
Number of pages | 3 |
Journal | Kidney International |
Volume | 91 |
Issue number | 2 |
DOIs |
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Publication status | Published - Feb 2017 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 International Society of Nephrology