Angiography-Based Fractional Flow Reserve: State of the Art

Alessandra Scoccia, Mariusz Tomaniak, Tara Neleman, Frederik T.W. Groenland, Annemieke C.Ziedses des Plantes, Joost Daemen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

8 Citations (Scopus)
4 Downloads (Pure)


Purpose of Review: Three-dimensional quantitative coronary angiography-based methods of fractional flow reserve (FFR) derivation have emerged as an appealing alternative to conventional pressure-wire-based physiological lesion assessment and have the potential to further extend the use of physiology in general. Here, we summarize the current evidence related to angiography-based FFR and perspectives on future developments. Recent Findings: Growing evidence suggests good diagnostic performance of angiography-based FFR measurements, both in chronic and acute coronary syndromes, as well as in specific lesion subsets, such as long and calcified lesions, left main coronary stenosis, and bifurcations. More recently, promising results on the superiority of angiography-based FFR as compared to angiography-guided PCI have been published. Summary: Currently available angiography -FFR indices proved to be an excellent alternative to invasive pressure wire-based FFR. Dedicated prospective outcome data comparing these indices to routine guideline recommended PCI including the use of FFR are eagerly awaited.

Original languageEnglish
Pages (from-to)667-678
Number of pages12
JournalCurrent Cardiology Reports
Issue number6
Early online date18 Apr 2022
Publication statusPublished - Jun 2022

Bibliographical note

Funding Information:
M. Tomaniak acknowledges funding as the laureate of the European Society of Cardiology Research and Training Program in the form of the ESC 2018 Grant (T-2018–19628).

Funding Information:
Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor Medical, and PulseCath. The authors declare that they have no conflict of interest.

Publisher Copyright:
© 2022, The Author(s).


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