Angiotensin II, oxidative stress and stem cell therapy: a matter of delicacy

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Abstract

Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming increasingly clear that the RAS affects the therapeutic performance of stem cells. In this issue of Clinical Science, Kankuri et al. dig deeper into the consequences of excessive angiotensin II signalling and reactive oxygen species (ROS) formation in the stem cell donor, applying a model of regenerative medicine after renal injury.
Original languageUndefined/Unknown
Pages (from-to)749-750
Number of pages2
JournalClinical Science
Volume128
Issue number11
DOIs
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09
  • EMC COEUR-09-39-02

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