Anthropometry-based prediction of body composition in early infancy compared to air-displacement plethysmography

Laurentya Olga, Inge A.L.P. van Beijsterveldt, Ieuan A. Hughes, David B. Dunger, Ken K. Ong, Anita C.S. Hokken-Koelega, Emanuella De Lucia Rolfe*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Anthropometry-based equations are commonly used to estimate infant body composition. However, existing equations were designed for newborns or adolescents. We aimed to (a) derive new prediction equations in infancy against air-displacement plethysmography (ADP-PEA Pod) as the criterion, (b) validate the newly developed equations in an independent infant cohort and (c) compare them with published equations (Slaughter-1988, Aris-2013, Catalano-1995). Methods: Cambridge Baby Growth Study (CBGS), UK, had anthropometry data at 6 weeks (N = 55) and 3 months (N = 64), including skinfold thicknesses (SFT) at four sites (triceps, subscapular, quadriceps and flank) and ADP-derived total body fat mass (FM) and fat-free mass (FFM). Prediction equations for FM and FFM were developed in CBGS using linear regression models and were validated in Sophia Pluto cohort, the Netherlands, (N = 571 and N = 447 aged 3 and 6 months, respectively) using Bland–Altman analyses to assess bias and 95% limits of agreement (LOA). Results: CBGS equations consisted of sex, age, weight, length and SFT from three sites and explained 65% of the variance in FM and 79% in FFM. In Sophia Pluto, these equations showed smaller mean bias than the three published equations in estimating FM: mean bias (LOA) 0.008 (−0.489, 0.505) kg at 3 months and 0.084 (−0.545, 0.713) kg at 6 months. Mean bias in estimating FFM was 0.099 (−0.394, 0.592) kg at 3 months and −0.021 (−0.663, 0.621) kg at 6 months. Conclusions: CBGS prediction equations for infant FM and FFM showed better validity in an independent cohort at ages 3 and 6 months than existing equations.

Original languageEnglish
Article numbere12818
JournalPediatric obesity
Volume16
Issue number11
Early online date10 Jun 2021
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

Funding Information:
Biotechnology and Biological Sciences Research Council, Grant/Award Number: BB/P028195/1; Danone Nutricia Research; EU Commission for JPI HDHL program ‘Call III Biomarkers’ for project: BioFN ‐ Biomarkers for Infant Fat Mass Development and Nutrition, Grant/Award Number: 696295; Medical Research Council Epidemiology Unit, Grant/Award Numbers: MC_UU_00006/2, MC_UU_12015/2; NIHR Cambridge Biomedical Research, Grant/Award Number: IS‐BRC‐1215‐20014; ZonMw, Grant/Award Number: 529051013 Funding information

Funding Information:
This work was supported by the EU Commission to the JPI HDHL program ?Call III Biomarkers? for the project: BioFN?Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in the Netherlands by the Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013) and UK by the Biotechnology and Biological Sciences Research Council (BB/P028195/1). This study also supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS-BRC-1215-20014). K.K.O. is supported by Medical Research Council Epidemiology Unit (MC_UU_12015/2 and MC_UU_00006/2). The views expressed are those of the authors and not necessarily those of the funders. The Sophia Pluto study is an investigator-initiated cohort study, for which A.C.S.H.K. received an independent research grant by Danone Nutricia Research. All CBGS and Sophia Pluto study sponsors had no role in the study design, collection, analysis or interpretation of the data, the writing of the manuscript or the decision to submit it for publication. The authors are grateful to the CBGS research nurses Suzanne Smith, Ann-Marie Wardell and Karen Forbes, Addenbrooke's Hospital, Cambridge. We thank all the families who contributed to the study, the staff at the NIHR-Wellcome Trust Clinical Research Facility, Cambridge the NIHR Cambridge Comprehensive Biomedical Research Centre and the midwives at the Rosie Maternity Hospital, Cambridge, UK. The authors want to thank all parents for their participation in the Sophia Pluto study and greatly acknowledge the research nurses Janneke van Nieuwkasteele, Christel Bruinings-Vroombout, Marianne Huibregtse-Schouten, Esther Lems, Naomi Khieroe, Suzanne Besteman-Voortman, Jose Bontenbal-van de Wege. This work was supported by the EU Commission to the JPI HDHL program ?Call III Biomarkers? for the project: BioFN?Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in the Netherlands by the Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013) and UK by the Biotechnology and Biological Sciences Research Council (BB/P028195/1). This study also supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS-BRC-1215-20014). K.K.O. is supported by Medical Research Council Epidemiology Unit (MC_UU_12015/2 and MC_UU_00006/2). The views expressed are those of the authors and not necessarily those of the funders. The Sophia Pluto study is an investigator-initiated cohort study, for which A.C.S.H.K. received an independent research grant by Danone Nutricia Research. All CBGS and Sophia Pluto study sponsors had no role in the study design, collection, analysis or interpretation of the data, the writing of the manuscript or the decision to submit it for publication.

Funding Information:
This work was supported by the EU Commission to the JPI HDHL program “Call III Biomarkers” for the project: BioFN—Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in the Netherlands by the Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013) and UK by the Biotechnology and Biological Sciences Research Council (BB/P028195/1). This study also supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS‐BRC‐1215‐20014). K.K.O. is supported by Medical Research Council Epidemiology Unit (MC_UU_12015/2 and MC_UU_00006/2). The views expressed are those of the authors and not necessarily those of the funders.

Publisher Copyright:
© 2021 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

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