Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

J. Zhai; J. Liao; M. Wang; Z. Huang; J. Hu; H. Xu; Q. Xie; B. Ma; C. C. Baan; Y. Wu

doi:10.1093/labmed/lmab046

Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

J. Zhai, J. Liao, M. Wang, Z. Huang, J. Hu, H. Xu, Q. Xie, B. Ma, C. C. Baan, Y. Wu^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

Original language	English
Pages (from-to)	156-160
Number of pages	5
Journal	Lab Medicine
Volume	53
Issue number	2
DOIs	https://doi.org/10.1093/labmed/lmab046
Publication status	Published - 1 Mar 2022

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© American Society for Clinical Pathology, 2021. All rights reserved.

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10.1093/labmed/lmab046

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125966218&doi=10.1093%2flabmed%2flmab046&partnerID=40&md5=cad67ec980596b8a5fd821cb4b90b786

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title = "Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis",

abstract = "Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.",

author = "J. Zhai and J. Liao and M. Wang and Z. Huang and J. Hu and H. Xu and Q. Xie and B. Ma and Baan, {C. C.} and Y. Wu",

year = "2022",

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doi = "10.1093/labmed/lmab046",

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T1 - Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

AU - Zhai, J.

AU - Liao, J.

AU - Wang, M.

AU - Huang, Z.

AU - Hu, J.

AU - Xu, H.

AU - Xie, Q.

AU - Ma, B.

AU - Baan, C. C.

AU - Wu, Y.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

AB - Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

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Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

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