Anti-Mullerian hormone (AMH): Regulator and marker of ovarian function

Leonie Houten, Axel Themmen, Jenny Visser

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

In this review, the role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS). (C) 2010 Elsevier Masson SAS. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)191-197
Number of pages7
JournalAnnales d' Endocrinologie
Volume71
Issue number3
DOIs
Publication statusPublished - 2010

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