Anti-Mullerian hormone (AMH): Regulator and marker of ovarian function

Leonie Houten; Axel Themmen; Jenny Visser

doi:10.1016/j.ando.2010.02.016

Anti-Mullerian hormone (AMH): Regulator and marker of ovarian function

Leonie Houten, Axel Themmen, Jenny Visser

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

76 Citations (Scopus)

Abstract

In this review, the role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS). (C) 2010 Elsevier Masson SAS. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	191-197
Number of pages	7
Journal	Annales d' Endocrinologie
Volume	71
Issue number	3
DOIs	https://doi.org/10.1016/j.ando.2010.02.016
Publication status	Published - 2010

Research programs

EMC MM-01-39-04

Access to Document

10.1016/j.ando.2010.02.016

http://hdl.handle.net/1765/70357

Cite this

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title = "Anti-Mullerian hormone (AMH): Regulator and marker of ovarian function",

abstract = "In this review, the role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS). (C) 2010 Elsevier Masson SAS. All rights reserved.",

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AU - Visser, Jenny

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AB - In this review, the role of anti-Mullerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS). (C) 2010 Elsevier Masson SAS. All rights reserved.

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