Abstract
The role of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) as a regulator of cell growth and differentiation is well recognized. Currently, 1,25-(OH)2D3 and vitamin D analogs are being evaluated for their therapeutic potential in the treatment of hyperproliferative disorders like cancer. In the present review, we will discuss several processes that might be involved in 1,25- (OH)2D3- and vitamin D analog-mediated suppression of cancer cell growth. The effects on tumor cell proliferation, differentiation, apoptosis, angiogenesis, metastases, and parathyroid hormone-related peptide secretion will be highlighted. In addition, combination therapy with other tumor effective drugs will be addressed. Furthermore, we will focus on the potential drawbacks and the possible side effects of vitamin D compounds in the treatment of cancer.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 717-732 |
| Number of pages | 16 |
| Journal | Current Pharmaceutical Design |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2000 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research programs
- EMC 02-01-38-02-00
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